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Title: Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters

Abstract

A process of preparing an acid addition salt of delta-aminolevulinic acid comprising: dissolving a lower alkyl 5-bromolevulinate and an alkali metal diformylamide in an organic solvent selected from the group consisting of acetonitrile, methanol, tetrahydrofuran, 2-methyltetrahydrofuran and methylformate or mixtures thereof to form a suspension of an alkyl 5-(N,N-diformylamino) levulinate ester; and hydrolyzing said alkyl 5-(N,N-diformylamino) levulinate with an inorganic acid to form an acid addition salt of delta-amino levulinic acid.

Inventors:
 [1]
  1. Lakewood, CO
Publication Date:
Research Org.:
Midwest Research Institute, Kansas City, MO (United States)
OSTI Identifier:
872302
Patent Number(s):
US 5907058
Assignee:
Midwest Research Institute (Kansas City, MO)
DOE Contract Number:  
AC36-83CH10093
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
synthesis; acid; addition; salt; delta-aminolevulinic; 5-bromo; levulinic; esters; process; preparing; comprising; dissolving; alkyl; 5-bromolevulinate; alkali; metal; diformylamide; organic; solvent; selected; consisting; acetonitrile; methanol; tetrahydrofuran; 2-methyltetrahydrofuran; methylformate; mixtures; form; suspension; 5-; n-diformylamino; levulinate; ester; hydrolyzing; inorganic; delta-amino; acid ester; organic solvent; alkali metal; inorganic acid; organic acid; acid esters; acid comprising; acid addition; levulinic acid; addition salt; solvent selected; delta-aminolevulinic acid; /999/

Citation Formats

Moens, Luc. Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters. United States: N. p., 1999. Web.
Moens, Luc. Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters. United States.
Moens, Luc. Fri . "Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters". United States. https://www.osti.gov/servlets/purl/872302.
@article{osti_872302,
title = {Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters},
author = {Moens, Luc},
abstractNote = {A process of preparing an acid addition salt of delta-aminolevulinic acid comprising: dissolving a lower alkyl 5-bromolevulinate and an alkali metal diformylamide in an organic solvent selected from the group consisting of acetonitrile, methanol, tetrahydrofuran, 2-methyltetrahydrofuran and methylformate or mixtures thereof to form a suspension of an alkyl 5-(N,N-diformylamino) levulinate ester; and hydrolyzing said alkyl 5-(N,N-diformylamino) levulinate with an inorganic acid to form an acid addition salt of delta-amino levulinic acid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

Patent:

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