Microinjector for blasocysts

Patent · 01 January 1999

OSTI ID:872171

Remenyik, Carl J ^[1]; Woychik, Richard P ^[2]; Patek, David R ^[3]; Hawk, James A ^[4]; Turner, John C ^[5]

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1. Knoxville, TN
2. Beechwood, OH
3. Loudon, TN
4. Oak Ridge, TN
5. Clinton, TN

An electromechanical device for driving the tip of a microinjection cannula, or needle, through the outer barrier of a blastocyst, cell, or cell nucleus for the injection of cells or other bioactive materials. Either a flexible frame or a ram moving within a base member is employed. Cannula motion is achieved by means of a piezoelectric stack and spring return system. The thrust motion over a predetermined microscopic distance is achieved without cannula setback prior to the thrust movement. Instead of specially prepared beveled and tipped needles, standard unimproved cannulas or needles can be used.

• Research Organization: LOCKHEED MARTIN ENERGY RES COR
• DOE Contract Number: AC05-96OR22464
• Assignee: Lockheed Martin Energy Research Corporation (Oak Ridge, TN)
• Patent Number(s): US 5877008
• OSTI ID: 872171
• Country of Publication: United States
• Language: English

Related Subjects

/435/73/
achieved
active material
active materials
barrier
base
beveled
bioactive
blasocysts
blastocyst
cannula
cannulas
cell
cells
device
distance
driving
electromechanical
employed
flexible
flexible frame
frame
injection
materials
means
mechanical device
microinjection
microinjector
microscopic
motion
movement
moving
needle
needles
nucleus
outer
piezoelectric
predetermined
prepared
prior
return
setback
specially
specially prepared
spring
spring return
stack
standard
thrust
tip
tipped
unimproved