Method for improved selectivity in photo-activation and detection of molecular diagnostic agents

Wachter, Eric A; Fisher, Walter G; Dees, H Craig

Title: Method for improved selectivity in photo-activation and detection of molecular diagnostic agents

Patent · Thu Jan 01 00:00:00 EST 1998

OSTI ID:871959

Wachter, Eric A ^[1]; Fisher, Walter G ^[2]; Dees, H Craig ^[2]

Oak Ridge, TN
Knoxville, TN

A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

DOE Contract Number:: AC05-84OR21400

Assignee:: Photogen, Inc. (Oak Ridge, TN)

Patent Number(s):: US 5832931

OSTI ID:: 871959

Country of Publication:: United States

Language:: English

References (50)

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Title: Method for improved selectivity in photo-activation and detection of molecular diagnostic agents

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