Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis
- Patchogue, NY
- Bellport, NY
- Islip, NY
Apparatus for performing organic synthetic reactions, particularly no-carrier-added nucleophilic radiofluorination reactions for PET radiotracer production. The apparatus includes an optical reaction cell and a source of broadband infrared radiant energy, which permits direct coupling of the emitted radiant energy with the reaction medium to heat the reaction medium. Preferably, the apparatus includes means for focusing the emitted radiant energy into the reaction cell, and the reaction cell itself is preferably configured to reflect transmitted radiant energy back into the reaction medium to further improve the efficiency of the apparatus. The apparatus is well suited to the production of high-yield syntheses of 2-›.sup.18 F!fluoro-2-deoxy-D-glucose. Also provided is a method for performing organic synthetic reactions, including the manufacture of ›.sup.18 F!-labeled compounds useful as PET radiotracers, and particularly for the preparation of 2-›.sup.18 F!fluoro-2-deoxy-D-glucose in higher yields than previously possible.
- Research Organization:
- Associated Universities, Inc., Upton, NY (United States)
- DOE Contract Number:
- AC02-76CH00016
- Assignee:
- Associated Universities, Inc. (Washington, DC)
- Patent Number(s):
- US 5808020
- Application Number:
- 08/694,398
- OSTI ID:
- 871843
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
reaction
cell
light
source
18f
fluoride
radiotracer
synthesis
apparatus
performing
organic
synthetic
reactions
particularly
no-carrier-added
nucleophilic
radiofluorination
pet
production
broadband
infrared
radiant
energy
permits
direct
coupling
emitted
medium
heat
preferably
means
focusing
configured
reflect
transmitted
improve
efficiency
suited
high-yield
syntheses
2-
18
fluoro-2-deoxy-d-glucose
provided
method
including
manufacture
-labeled
compounds
useful
radiotracers
preparation
yields
previously
compounds useful
reaction medium
synthesis apparatus
radiant energy
light source
reaction cell
labeled compounds
permits direct
radiotracer synthesis
direct coupling
/999/204/422/