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Title: GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person

Patent ·
OSTI ID:871841
 [1];  [2];  [3];  [3];  [4]
  1. 3125 Bolgos Cir., Ann Arbor, MI 48105
  2. 8309 Norris Canyon, Castro Valley, CA 94552
  3. 5, rue du Cannau, 34000 Montpellier, FR
  4. 3164 Concord, Trenton, MI 48183
+ Show Author Affiliations

The gene encoding GDP-L-fucose: .beta.-D-Galactoside 2-.alpha.-L-fucosyltransferase has been cloned, and a mutation in this gene has been found to be responsible for an individual being a non-secretor.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
DOE Contract Number:
W-7405-ENG-48
Assignee:
Lowe, John B. (3125 Bolgos Cir., Ann Arbor, MI 48105);Lennon, Gregory (8309 Norris Canyon, Castro Valley, CA 94552);Rouquier, Sylvie (5, rue du Cannau, 34000 Montpellier, FR);Giorgi, Dominique (5, rue du Cannau, 34000 Montpellier, FR);Kelly, Robert J. (3164 Concord, Trenton, MI 48183)
Patent Number(s):
US 5807732
OSTI ID:
871841
Country of Publication:
United States
Language:
English

References (46)

Cloning and sequencing of cDNA of bovine N-acetylglucosamine (beta 1-4)galactosyltransferase. journal July 1986
Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant journal June 1994
Enzymatic basis for the accumulation of glycolipids with X and dimeric X determinants in human lung cancer cells (NCI-H69). journal June 1985
Molecular cloning and biological characterization of a human gene, ERCC2, that corrects the nucleotide excision repair defect in CHO UV5 cells. journal March 1988
Controlled Linkage Techniques for Monosaccharides Introduced: Methods allow automation of oligosaccharide production, offer route, similar to oligopeptide synthesis, to specialized carbohydrates journal August 1989
Stable transformation of mouse L cells for human membrane T-cell differentiation antigens, HLA and beta 2-microglobulin: selection by fluorescence-activated cell sorting. journal January 1983
Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant. journal August 1994
Purification of the beta-N-acetylglucosaminide alpha 1----3-fucosyltransferase from human serum. journal February 1992
Purification and characterization of a UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase from Ehrlich ascites tumor cells. journal May 1986
The isolation and sequence of the gene encoding T8: A molecule defining functional classes of T lymphocytes journal February 1985
The cloning and expression of a human α-1,3 fucosyltransferase capable of forming the E-selectin ligand journal August 1992
Capitalizing on Carbohydrates journal February 1990
Co-transformation of Lec1 CHO cells with N-acetylgucosaminyltransferase 1 activity and a selectable marker journal March 1990
Co-purification of the Lewis blood group N-acetylglucosaminide alpha 1 goes to 4 fucosyltransferase and an N-acetylglucosaminide alpha 1 goes to 3 fucosyltransferase from human milk. journal October 1981
Protective effects of sialylated oligosaccharides in immune complex-induced acute lung injury. journal August 1993
Biosynthesis of terminal Gal alpha 1—-3Gal beta 1—-4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1—-3-galactosyltransferase from calf thymus. journal October 1985
Acceptor specificity and tissue distribution of three human alpha-3-fucosyltransferases journal July 1990
A Cloned Human DNA Restriction Fragment Determines Expression of a GDP-L-fucose:β-D-Galactoside 2-α-L-fucosytransferase in Transfected Cells journal July 1989
Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland. journal June 1980
Bovine galactosyltransferase: identification of a clone by direct immunological screening of a cDNA expression library. journal March 1986
Molecular Cloning and Expression of Two Types of Rabbit β-Galactoside α1,2-Fucosyltransferase journal April 1995
Gene transfer, expression, and molecular cloning of the human transferrin receptor gene journal May 1984
Enzyme-catalyzed synthesis of carbohydrates journal January 1989
Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland. journal June 1980
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor journal July 1978
A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase. journal August 1990
Gene transfer and molecular cloning of the human NGF receptor journal April 1986
Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes. journal December 1992
Stable Expression of Blood Group H Determinants and GDP-L-fucose: β-D-galactoside 2-α-L-Fucosyltransferase in Mouse Cells After Transfection with Human DNA journal February 1989
A new technique for the assay of infectivity of human adenovirus 5 DNA journal April 1973
Purification of theN-acetylglucosaminide ?(1?3/4) fucosyltransferase of human milk journal January 1989
Purification of the secretor-type beta-galactoside alpha 1----2-fucosyltransferase from human serum. journal February 1992
DNA-mediated transformation of N-acetylglucosaminyltransferase I activity into an enzyme deficient cell line journal March 1989
Primary structure of beta-galactoside alpha 2,6-sialyltransferase. Conversion of membrane-bound enzyme to soluble forms by cleavage of the NH2-terminal signal anchor. journal December 1987
Protective effects of oligosaccharides in P-selectin-dependent lung injury journal July 1993
[26] Cloning genes for bacterial glycosyltransferases book January 1982
Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen. journal September 1990
Isolation of a cDNA encoding a murine UDPgalactose:beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase: expression cloning by gene transfer. journal November 1989
Purification of a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase and a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase to homogeneity from rat liver. journal November 1982
Human α-1,3 Fucosyltransferase (FucT-VI) Gene Is Located at Only 13 kb 3′ to the Lewis Type Fucosyltransferase (FucT-III) Gene on Chromosome 19 journal January 1993
Sequence and Expression of a Candidate for the Human Secretor Blood Group α(1,2)Fucosyltransferase Gene (FUT2) journal March 1995
Isolation of a cDNA coding for human galactosyltransferase journal August 1986
Evidence for two distinct α(1,2)-fucosyltransferase genes differentially expressed throughout the rat colon journal June 1994
Purification and Characterization of Secretory-Type GDP-L-Fucose: β-D-Galactoside 2-α-L-Fucosyltransferase from Human Gastric Mucosa1 journal September 1995
Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes. journal May 1994
Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. journal February 1992

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Related Subjects

gdp-l-fucose
beta
-d-galactoside
2-
alpha
-l-fucosyltransferases
dna
sequences
encoding
method
producing
genotyping
person
-l-fucosyltransferase
cloned
mutation
found
responsible
individual
non-secretor
sequences encoding
dna sequences
dna sequence
/435/999/