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Title: Resonant-cavity apparatus for cytometry or particle analysis

Patent ·
OSTI ID:871776
 [1]
  1. Albuquerque, NM
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A resonant-cavity apparatus for cytometry or particle analysis. The apparatus comprises a resonant optical cavity having an analysis region within the cavity for containing one or more biological cells or dielectric particles to be analyzed. In the presence of a cell or particle, a light beam in the form of spontaneous emission or lasing is generated within the resonant optical cavity and is encoded with information about the cell or particle. An analysis means including a spectrometer and/or a pulse-height analyzer is provided within the apparatus for recovery of the information from the light beam to determine a size, shape, identification or other characteristics about the cells or particles being analyzed. The recovered information can be grouped in a multi-dimensional coordinate space for identification of particular types of cells or particles. In some embodiments of the apparatus, the resonant optical cavity can be formed, at least in part, from a vertical-cavity surface-emitting laser. The apparatus and method are particularly suited to the analysis of biological cells, including blood cells, and can further include processing means for manipulating, sorting, or eradicating cells after analysis thereof.

Research Organization:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
DOE Contract Number:
AC04-94AL85000
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Number(s):
US 5793485
OSTI ID:
871776
Country of Publication:
United States
Language:
English

References (9)

Semiconductor microlasers: A new approach to cell–structure analysis journal August 1996
Intracavity spectroscopy in vertical cavity surface‐emitting lasers for micro‐optical‐mechanical systems journal September 1996
Vertical cavity surface-emitting laser scanning cytometer for high-speed analysis of cells conference April 1996
Lasers and fiber optics in medicine conference June 1993
Surface-emitting semiconductor laser for intracavity spectroscopy and microscopy report March 1995
Optically accessible microchannels formed in a single-crystal silicon substrate for studies of blood rheology journal September 1992
Surface-emitting semiconductor laser spectroscopy and microscopy for characterizing normal and sickled red blood cells conference April 1995
The Blood book January 1983
Optical trapping and manipulation of single cells using infrared laser beams journal December 1987

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resonant-cavity
apparatus
cytometry
particle
analysis
comprises
resonant
optical
cavity
region
containing
biological
cells
dielectric
particles
analyzed
presence
cell
light
beam
form
spontaneous
emission
lasing
generated
encoded
information
means
including
spectrometer
pulse-height
analyzer
provided
recovery
determine
size
shape
identification
characteristics
recovered
multi-dimensional
coordinate
space
particular
types
embodiments
formed
vertical-cavity
surface-emitting
laser
method
particularly
suited
blood
processing
manipulating
sorting
eradicating
cavity surface
analysis region
surface-emitting laser
resonant optical
vertical-cavity surface-emitting
means including
particularly suited
optical cavity
blood cells
apparatus comprises
light beam
biological cells
processing means
blood cell
apparatus comprise
particular type
particle analysis
spontaneous emission
emitting laser
height analyzer
resonant-cavity apparatus
biological cell
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