Rigid bifunctional chelating agents

Patent · 21 July 1998

OSTI ID:871721

Sweet, Mark P ^[1]; Mease, Ronnie C ^[2]; Srivastava, Suresh C ^[3]

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1. Coram, NY
2. Fairfax, VA
3. Setauket, NY

Bicyclo›2.2.2! octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo›2.2.1! heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

• Research Organization: ASSOC UNIVERSITIES INC
• DOE Contract Number: AC02-76CH00016
• Assignee: Brookhaven Science Associates LLC (Upton, NY)
• Patent Number(s): US 5783169
• Application Number: 08/506,889
• OSTI ID: 871721
• Country of Publication: United States
• Language: English

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