Fluorescent labels and their use in separations
Patent
·
OSTI ID:871087
- El Cerrito, CA
- Orinda, CA
- Berkeley, CA
Compositions are provided comprising sets of fluorescent labels carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility under separation conditions, by varying the distance between the donor and acceptor in a given pair. Particularly, the fluorescent compositions find use as labels in sequencing nucleic acids.
- Research Organization:
- Univ. of California (United States)
- DOE Contract Number:
- FG03-91ER61125
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Number(s):
- US 5654419
- OSTI ID:
- 871087
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
fluorescent
labels
separations
compositions
provided
comprising
sets
carrying
pairs
donor
acceptor
dye
molecules
designed
efficient
excitation
donors
single
wavelength
emission
wavelengths
donor-acceptor
modified
substantially
mobility
separation
conditions
varying
distance
pair
particularly
sequencing
nucleic
acids
nucleic acid
provided comprising
nucleic acids
dye molecules
separation conditions
fluorescent labels
single wavelength
comprising sets
fluorescent composition
acceptor pair
carrying pairs
acceptor dye
efficient excitation
labels carrying
/999/435/436/
labels
separations
compositions
provided
comprising
sets
carrying
pairs
donor
acceptor
dye
molecules
designed
efficient
excitation
donors
single
wavelength
emission
wavelengths
donor-acceptor
modified
substantially
mobility
separation
conditions
varying
distance
pair
particularly
sequencing
nucleic
acids
nucleic acid
provided comprising
nucleic acids
dye molecules
separation conditions
fluorescent labels
single wavelength
comprising sets
fluorescent composition
acceptor pair
carrying pairs
acceptor dye
efficient excitation
labels carrying
/999/435/436/