New multifunctional ligands for potential use in the design therapeutic or diagnostic radiopharmaceutical imaging agents

Katti, Kattesh V; Volkert, Wynn A; Ketring, Alan R; Singh, Prahlad R

New multifunctional ligands for potential use in the design therapeutic or diagnostic radiopharmaceutical imaging agents

Patent · 01 January 1997

OSTI ID:870821

Katti, Kattesh V ^[1]; Volkert, Wynn A ^[1]; Ketring, Alan R ^[1]; Singh, Prahlad R ^[1]

Columbia, MO

A class of diagnostic and therapeutic compounds derived from phosphinimines that include ligands containing either a single phosphinimine functionality or both a phosphinimine group and a phosphine or arsine group, or an aminato group, or a second phosphinimine moiety. These phosphinimine ligands are complexed to early transition metal radionuclides (e.g. .sup.99m Tc or .sup.186 Re/.sup.188 Re) or late transition metals (e.g., .sup.105 Rh or .sup.109 Pd). The complexes with these metals .sup.186 Re/.sup.188 Re, .sup.99m Tc and .sup.109 Pd exhibit a high in vitro and high in vivo stability. The complexes are formed in high yields and can be neutral or charged. These ligands can also be used to form stable compounds with paramagnetic transition metals (e.g. Fe and Mn) for potential use as MRI contrast agents. Applications for the use of ligands and making the ligands are also disclosed.

View Patent

Research Organization:: University of Missouri

DOE Contract Number:: FG02-89ER60875

Assignee:: Curators of University of Missouri (Columbia, MO)

Patent Number(s):: US 5601800

OSTI ID:: 870821

Country of Publication:: United States

Language:: English

References (30)

Gd-DPTA: an i.v. contrast agent for clinical MRI Runge, Val M. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 15, Issue 1 https://doi.org/10.1016/0883-2897(88)90158-4	journal	January 1988
Chelates and antibodies: Current methods and new directions Gansow, Otto A.; Brechbiel, Martin W.; Mirzadeh, Saed Cancer Imaging with Radiolabeled Antibodies https://doi.org/10.1007/978-1-4613-1497-4_7	book	January 1990
Radionuclide selection and model absorbed dose calculations for radiolabeled tumor associated antibodies: Radionuclide selection and dose calculations for labeled antibodies Wessels, Barry W.; Rogus, Ronald D. Medical Physics, Vol. 11, Issue 5 https://doi.org/10.1118/1.595559	journal	September 1984
Stabilization of rhodium(I)- and iridium(I)-alkyl bonds by intramolecular coordination of an iminophosphorane. X-ray crystal structure of [Rh(CH2PPh2:NC6H4CH3-4)(COD)] Imhoff, Pieter; Nefkens, Sylvia C. A.; Elsevier, Cornelis Organometallics, Vol. 10, Issue 5 https://doi.org/10.1021/om00051a038	journal	May 1991
Synthesis and in vivo testing of a bromobutyl substituted 1,2-dithia-5,9-diazacycloundecane: a versatile precursor for new 99mTc-bis(aminoethanethiol) complexes Eisenhut, M.; Brandau, W.; Miβfeldt, M. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 16, Issue 8 https://doi.org/10.1016/0883-2897(89)90165-7	journal	January 1989
Interposition of different chemical linkages between antibody and 111In-DTPA to accelerate clearance from non-target organs and blood Paik, Chang H.; Quadri, Syed M.; Reba, Richard C. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 16, Issue 5 https://doi.org/10.1016/0883-2897(89)90059-7	journal	January 1989
Progress in research on ligands, nuclides and techniques for labeling monoclonal antibodies Srivastava, Suresh C.; Mease, Ronnie C. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 18, Issue 6 https://doi.org/10.1016/0883-2897(91)90029-K	journal	January 1991
Current and future radiopharmaceuticals for brain imaging with single photon emission computed tomography Kung, Hank F.; Ohmomo, Yoshiro; Kung, Mei-Ping Seminars in Nuclear Medicine, Vol. 20, Issue 4 https://doi.org/10.1016/S0001-2998(05)80235-1	journal	October 1990
The Radiobiology of Targeted Radiotherapy Wheldon, T. E.; O'Donoghue, J. A. International Journal of Radiation Biology, Vol. 58, Issue 1 https://doi.org/10.1080/09553009014551401	journal	January 1990
Production and Use of Prospective Radionuclides for Radioimmunotherapy Mausner, Leonard F.; Straub, Rita F.; Srivastava, Suresh C. Radiolabeled Monoclonal Antibodies for Imaging and Therapy https://doi.org/10.1007/978-1-4684-5538-0_12	book	January 1988
Tumour targeting with radiolabelled macrocycle–antibody conjugates Parker, David Chem. Soc. Rev., Vol. 19, Issue 3 https://doi.org/10.1039/CS9901900271	journal	January 1990
Covalent attachment of chelating groups to macromolecules Krejcarek, Gary E.; Tucker, Karen L. Biochemical and Biophysical Research Communications, Vol. 77, Issue 2 https://doi.org/10.1016/S0006-291X(77)80018-1	journal	July 1977
2 The clinical use of somatostatin analogues in the treatment of cancer Lamberts, Steven W. J.; Krenning, Eric P.; Klijn, Jan G. M. Baillière's Clinical Endocrinology and Metabolism, Vol. 4, Issue 1 https://doi.org/10.1016/S0950-351X(05)80314-3	journal	March 1990
The Chemistry of Phosphinimines Abel, E. W.; Mucklejohn, S. A. Phosphorus and Sulfur and the Related Elements, Vol. 9, Issue 3 https://doi.org/10.1080/03086648108078247	journal	January 1981
Preparation and structural characterization of salts of oxotetrachlorotechnetate(V) Cotton, F. Albert; Davison, Alan; Day, Victor W. Inorganic Chemistry, Vol. 18, Issue 11 https://doi.org/10.1021/ic50201a016	journal	November 1979
Progestin-rhenium complexes: metal-labeled steroids with high receptor binding affinity, potential receptor-directed agents for diagnostic imaging or therapy DiZio, James P.; Fiaschi, Rita; Davison, Alan Bioconjugate Chemistry, Vol. 2, Issue 5 https://doi.org/10.1021/bc00011a011	journal	September 1991
Some triphenylphosphinimine complexes of zinc, cadmium, mercury, rhodium and palladium Abel, Edward W.; Mucklejohn, Stuart A. Inorganica Chimica Acta, Vol. 37 https://doi.org/10.1016/S0020-1693(00)95526-9	journal	January 1979
Bifunctional chelating agents for radiometal-labeled monoclonal antibodies Subramanian, Ramaswamy; Meares, Claude F. Cancer Imaging with Radiolabeled Antibodies https://doi.org/10.1007/978-1-4613-1497-4_9	book	January 1990
Radiolabeled Phosphonic acid Chelates: Potential Therapeutic Agents for Treatment of Skeletal Metastases Volkert, W. A.; Simon, J.; Ketring, A. R. Drugs of the Future, Vol. 14, Issue 8 https://doi.org/10.1358/dof.1989.014.08.103343	journal	January 1989
Pharmacokinetics and clinical application of technetium 99m-labeled hepatobiliary agents Krishnamurthy, Gerbail T.; Turner, Fredrick E. Seminars in Nuclear Medicine, Vol. 20, Issue 2 https://doi.org/10.1016/S0001-2998(05)80166-7	journal	April 1990
Radiopharmaceuticals for imaging myocardial perfusion Nunn, A. D. Seminars in Nuclear Medicine, Vol. 20, Issue 2 https://doi.org/10.1016/S0001-2998(05)80164-3	journal	April 1990
The chemistry of 99mTc-labeled radiopharmaceuticals Dewanjee, Mrinal K. Seminars in Nuclear Medicine, Vol. 20, Issue 1 https://doi.org/10.1016/S0001-2998(05)80173-4	journal	January 1990
Novel bifunctional linkers for antibody chelation with radiometals Wu, Robert Sundoro Cancer Imaging with Radiolabeled Antibodies https://doi.org/10.1007/978-1-4613-1497-4_11	book	January 1990
The chemistry of rhenium and technetium as related to the use of isotopes of these elements in therapeutic and diagnostic nuclear medicine Deutsch, Edward; Libson, Karen; Vanderheyden, Jean-Luc International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 13, Issue 4 https://doi.org/10.1016/0883-2897(86)90027-9	journal	January 1986
Advances in contrast-enhanced MR imaging. Principles. Saini, S. American Journal of Roentgenology, Vol. 156, Issue 2 https://doi.org/10.2214/ajr.156.2.1898792	journal	February 1991
Transition Metal Chemistry of a Novel and Versatile Heterodifunctional Phosphorus-Nitrogen Ligand System Katti, K. V.; Cavell, R. G. Comments on Inorganic Chemistry, Vol. 10, Issue 2-3 https://doi.org/10.1080/02603599008050858	journal	May 1990
Technetium-99m spiperone dithiocarbamate: A potential radiopharmaceutical for dopamine receptor imaging with SPECT Ballinger, James R.; Gulenchyn, Karen Y.; Hassan, Mohamed N. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 40, Issue 6 https://doi.org/10.1016/0883-2889(89)90145-7	journal	January 1989
High oxidation state technetium and rhenium complexes of hydrotris(1-pyrazolyl)borate Thomas, John Anthony; Davison, Alan Inorganica Chimica Acta, Vol. 190, Issue 2 https://doi.org/10.1016/S0020-1693(00)80258-3	journal	December 1991
Copper chelates as probes of biological systems: Stable copper complexes with a macrocyclic bifunctional chelating agent Moi, Min K.; Meares, Claude F.; McCall, Michael J. Analytical Biochemistry, Vol. 148, Issue 1 https://doi.org/10.1016/0003-2697(85)90653-0	journal	July 1985
Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent. Fritzberg, A. R.; Abrams, P. G.; Beaumier, P. L. Proceedings of the National Academy of Sciences, Vol. 85, Issue 11 https://doi.org/10.1073/pnas.85.11.4025	journal	June 1988

Similar Records

New multifunctional ligands for potential use in the design therapeutic or diagnostic radiopharmaceutical imaging agents

Patent · 1997 · OSTI ID:441867

Biomolecule conjugation strategy using novel water-soluble phosphine-based chelating agents

Patent · 2004 · OSTI ID:1174992

Radiolabeling proteins with bifunctional chelating agents

Thesis/Dissertation · 1991 · OSTI ID:7165643

Related Subjects

/424/999/
105
109
186
188
99m
agents
aminato
applications
arsine
charged
complexed
complexes
compounds
containing
contrast
contrast agent
contrast agents
derived
design
diagnostic
diagnostic radiopharmaceutical
disclosed
exhibit
form
form stable
formed
functionality
imaging
imaging agent
imaging agents
ligands
metal
metals
mn
moiety
mri
multifunctional
multifunctional ligand
neutral
paramagnetic
pd
phosphine
phosphinimine
phosphinimines
potential
radionuclides
radiopharmaceutical
radiopharmaceutical imaging
single
stability
stable
stable compound
tc
therapeutic
therapeutic compounds
transition
transition metal
transition metals
vitro
vivo
yields

New multifunctional ligands for potential use in the design therapeutic or diagnostic radiopharmaceutical imaging agents

Citation Formats

References (30)

Similar Records

Related Subjects