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Title: Self-assembling multimeric nucleic acid constructs

Patent ·
OSTI ID:870622
 [1];  [2];  [1];  [1];  [3];  [4]
  1. Boston, MA
  2. Bremen, DE
  3. Brookline, MA
  4. Southborough, MA
+ Show Author Affiliations

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products.

Research Organization:
Boston University
DOE Contract Number:
FG02-93ER61656
Assignee:
Trustees of Boston University (Boston, MA)
Patent Number(s):
US 5561043
OSTI ID:
870622
Country of Publication:
United States
Language:
English

References (6)

Amplifying DNA Probe Signals: A ‘christmas Tree’ Approach journal October 1988
Affinity capture electrophoresis for sequence-specific DNA purification journal June 1992
Immuno-PCR with a commercially available avidin system journal April 1993
Atomic force microscopy of biochemically tagged DNA. journal May 1993
[66] Biotinylated nucleotides for labeling and detecting DNA book January 1990
Sequence-specific DNA purification by triplex affinity capture. journal January 1992

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Related Subjects

self-assembling
multimeric
nucleic
acid
constructs
directed
compositions
containing
forms
acids
comprise
single-stranded
attached
via
biotin
streptavidin
bound
functional
utilized
vivo
treat
identify
diseased
tissue
cells
repeated
administrations
produce
rapid
specific
amplification
treatment
purposes
toxins
radioisotopes
genes
enzymes
diagnostically
labeled
targets
vitro
nanotechnology
create
polymeric
aggregates
membranes
defined
porosity
microcircuits
products
nucleic acid
nucleic acids
compositions containing
single-stranded nucleic
multimeric nucleic
specific target
identify specific
attached via
acid constructs
self-assembling multimeric
compositions contain
compositions produce
comprise single-stranded
multimeric forms
diseased tissue
via biotin
stranded nucleic
acids attached
acids comprise
containing multimeric
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