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Title: Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography

Patent ·
OSTI ID:870246
 [1];  [2];  [3]
  1. Patchogue, NY
  2. Bellport, NY
  3. Westhampton, NY
+ Show Author Affiliations

A handling and processing apparatus for preparing Oxygen-15 labeled water (H.sub.2 [.sup.15 O]) in injectable form for use in Positron Emission Tomography from preferably H.sub.2 [.sup.15 O] produced by irradiating a flowing gas target of nitrogen and hydrogen. The apparatus includes a collector for receiving and directing a gas containing H.sub.2 [.sup.15 O] gas and impurities, mainly ammonia (NH.sub.3) gas into sterile water to trap the H.sub.2 [.sup.15 O] and form ammonium (NH.sub.4.sup.+) in the sterile water. A device for displacing the sterile water containing H.sub.2 [.sup.15 O] and NH.sub.4.sup.+ through a cation resin removes NH.sub.4.sup.+ from the sterile water. A device for combining the sterile water containing H.sub.2 [.sup.15 O] with a saline solution produces an injectable solution. Preferably, the apparatus includes a device for delivering the solution to a syringe for injection into a patient. Also, disclosed is a method for preparing H.sub.2 [.sup.15 O] in injectable form for use in Positron Emission Tomography in which the method neither requires isotopic exchange reaction nor application of high temperature.

Research Organization:
Associated Universities, Inc., Upton, NY (United States)
DOE Contract Number:
AC02-76CH00016
Assignee:
Associated Universities, Inc. (Washington, DC)
Patent Number(s):
US 5482865
Application Number:
08/258,053
OSTI ID:
870246
Country of Publication:
United States
Language:
English

References (5)

Low-carrier production of [15O]oxygen, water and carbon monoxide
  • Berridge, M. S.; Terris, A. H.; Cassidy, E. H.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 41, Issue 12 https://doi.org/10.1016/0883-2889(90)90202-R
journal January 1990
Current methodology for oxygen-15 production for clinical use journal January 1987
A remote system for the routine production of oxygen-15 radiopharmaceuticals journal November 1985
Direct synthesis of oxygen-15 labelled water at high specific activities journal October 1978
Direct simultaneous production of [15O]water and [13N]ammonia or [18F]fluoride ion by 26 MeV proton irradiation of a double chamber water target
  • Mulholland, G. Keith; Kilbourn, Michael R.; Moskwa, James J.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 41, Issue 12 https://doi.org/10.1016/0883-2889(90)90206-V
journal January 1990

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Related Subjects

apparatus
method
preparing
oxygen-15
labeled
water
15
injectable
form
positron
emission
tomography
handling
processing
preferably
produced
irradiating
flowing
gas
target
nitrogen
hydrogen
collector
receiving
directing
containing
impurities
mainly
ammonia
nh
sterile
trap
ammonium
device
displacing
cation
resin
removes
combining
saline
solution
produces
delivering
syringe
injection
patient
disclosed
neither
requires
isotopic
exchange
reaction
nor
application
temperature
saline solution
gas containing
emission tomography
positron emission
water containing
processing apparatus
flowing gas
exchange reaction
oxygen-15 labeled
gas target
injectable form
preparing oxygen-15
labeled water
/436/250/376/422/