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Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

Patent ·
OSTI ID:870091
 [1];  [2]
  1. Hampton Bays, NY
  2. Southold, NY
+ Show Author Affiliations

A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

Research Organization:
ASSOC UNIVERSITIES INC
DOE Contract Number:
AC02-76CH00016
Assignee:
Associated Universities, Inc. (Washington, DC)
Patent Number(s):
US 5455022
Application Number:
08/118,300
OSTI ID:
870091
Country of Publication:
United States
Language:
English

References (8)

Boron neutron capture therapy of intracerebral rat gliosarcomas. journal December 1990
Synthesis and chemistry of mercaptoundecahydro-closo-dodecaborate(2-) journal October 1978
Uranium-loaded apoferritin with antibodies attached: molecular design for uranium neutron-capture therapy. journal November 1992
Biodistribution and toxicity of 2,4-divinyl-nido-o-carboranyldeuteroporphyrin IX in mice journal February 1992
An Extravascular Component of Contrast Enhancement in Cranial Computed Tomography: Part I: The Tissue—Blood Ratio of Contrast Enhancement journal December 1975
Chemistry of Boranes. IX. Halogenation of B 10 H 10 -2 and B 12 H 12 -2 journal February 1964
A History of Boron Neutron Capture Therapy of Brain Tumours: Postulation of a Brain Radiation dose Tolerance Limit journal January 1991
Boron uptake in melanoma, cerebrum and blood from Na2B12H11SH and Na4B24H22S2 administered to mice journal May 1986

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