Catalytic and reactive polypeptides and methods for their preparation and use

Schultz, Peter

Title: Catalytic and reactive polypeptides and methods for their preparation and use

Patent · Sat Jan 01 00:00:00 EST 1994

OSTI ID:869234

Schultz, Peter ^[1]

Oakland, CA

Catalytic and reactive polypeptides include a binding site specific for a reactant or reactive intermediate involved in a chemical reaction of interest. The polypeptides further include at least one active functionality proximate the binding site, where the active functionality is capable of catalyzing or chemically participating in the chemical reaction in such a way that the reaction rate is enhanced. Methods for preparing the catalytic peptides include chemical synthesis, site-directed mutagenesis of antibody and enzyme genes, covalent attachment of the functionalities through particular amino acid side chains, and the like.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

DOE Contract Number:: C87-101226

Assignee:: Regents of University of California (Berkeley, CA)

Patent Number(s):: US 5302516

OSTI ID:: 869234

Country of Publication:: United States

Language:: English

References (48)

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Title: Catalytic and reactive polypeptides and methods for their preparation and use

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