Catalytic and reactive polypeptides and methods for their preparation and use

Schultz, Peter

Title: Catalytic and reactive polypeptides and methods for their preparation and use

Abstract

Catalytic and reactive polypeptides include a binding site specific for a reactant or reactive intermediate involved in a chemical reaction of interest. The polypeptides further include at least one active functionality proximate the bi.

Inventors:

Schultz, Peter ^[1]

Oakland, CA

Publication Date:: Fri Jan 01 00:00:00 EST 1993

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

OSTI Identifier:: 868799

Patent Number(s):: US 5215889

Assignee:: Regents of University of California (Oakland, CA)

DOE Contract Number:: C87-101226

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: catalytic; reactive; polypeptides; methods; preparation; binding; site; specific; reactant; intermediate; involved; chemical; reaction; active; functionality; proximate; reactive polypeptides; binding site; chemical reaction; site specific; /435/530/

Citation Formats


                    Schultz, Peter. Catalytic and reactive polypeptides and methods for their preparation and use.  United States: N. p., 1993. 
        Web.

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                    Schultz, Peter. Catalytic and reactive polypeptides and methods for their preparation and use.  United States.

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                    Schultz, Peter. 1993.  
        "Catalytic and reactive polypeptides and methods for their preparation and use".  United States.  https://www.osti.gov/servlets/purl/868799.

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@article{osti_868799,

  title        = {Catalytic and reactive polypeptides and methods for their preparation and use},

  author       = {Schultz, Peter},

  abstractNote = {Catalytic and reactive polypeptides include a binding site specific for a reactant or reactive intermediate involved in a chemical reaction of interest. The polypeptides further include at least one active functionality proximate the bi.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/868799},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Fri Jan 01 00:00:00 EST 1993},

  month        = {Fri Jan 01 00:00:00 EST 1993}

}

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Works referenced in this record:

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Chemical mutation of enzyme active sites
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Photosensitized cleavage of a thymine dimer by an antibody
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Catalytic antibodies
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Directed mutagenesis of the redox-active disulfide in the flavoenzyme mercuric ion reductase
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Introduction of nucleophiles and spectroscopic probes into antibody combining sites
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Similar Records

Title: Catalytic and reactive polypeptides and methods for their preparation and use

Abstract

Citation Formats

Antibody Catalysis by Transition State Stabilization journal, January 1987

Designer catalytic antibodies journal, March 1989

Catalysis of concerted reactions by antibodies: the Claisen rearrangement. journal, July 1988

Transaminations by pyridoxamine selectively attached at C-3 in .beta.-cyclodextrin journal, March 1983

Principles of antibody catalysis journal, October 1988

Antibody-enzyme analogy. Characterization of antibodies to phosphopyridoxyltyrosine derivatives journal, February 1975

Engineering antibody affinity and specificity journal, January 1988

A-(modified B6)-B-[.omega.-amino(ethylamino)]-.beta.-cyclodextrin as an artificial B6 enzyme for chiral aminotransfer reaction journal, September 1985

Intramolecular general base-acid catalysis in transaminations catalyzed by pyridoxamine enzyme analogs journal, March 1983

Induction of an antibody that catalyzes the hydrolysis of an amide bond journal, September 1988

Catalytic antibodies journal, April 1987

Host-guest complexation. 31. A transacylase partial mimic journal, August 1984

Catalysis and chiral recognition through designed complexation of transition states in transacylations of amino ester salts journal, February 1976

Molecular catalysis: enhanced rates of thiolysis with high structural and chiral recognition in complexes of a reactive macrocyclic receptor molecule journal, January 1978

Artificial enzymes journal, November 1982

Antibody catalysis approaching the activity of enzymes journal, March 1988

Generation of a hybrid sequence-specific single-stranded deoxyribonuclease journal, December 1987

A stereospecific cyclization catalyzed by an antibody journal, August 1987

The conversion of serine at the active site of subtilisin to cysteine: a "chemical mutation". journal, November 1966

Cyclodextrin catalysis as a model for enzyme action journal, March 1982

Antibody catalysis of bimolecular amide formation journal, July 1988

Chemical mutation of enzyme active sites journal, November 1984

Photosensitized cleavage of a thymine dimer by an antibody journal, November 1988

Purification and properties of thiol beta-lactamase. A mutant of pBR322 beta-lactamase in which the active site serine has been replaced with cysteine. journal, April 1984

An antibody-catalyzed Claisen rearrangement journal, July 1988

Synthesis of the Myoglobin Active Site journal, September 1973

Oligonucleotide-directed mutagenesis as a general and powerful method for studies of protein function. journal, November 1982

Synthetic models for the oxygen-binding hemoproteins journal, July 1977

Catalytic antibodies journal, December 1986

Directed mutagenesis of the redox-active disulfide in the flavoenzyme mercuric ion reductase journal, November 1985

Introduction of nucleophiles and spectroscopic probes into antibody combining sites journal, November 1988

Selective chemical catalysis by an antibody journal, December 1986

Localization of affinity-labeled residues on the heavy and light chain of two myeloma proteins with anti-hapten activity journal, June 1972

Redesigning trypsin: alteration of substrate specificity journal, April 1985

Monoclonal immunoglobulin G augments hydrolysis of an ester of the homologous hapten: An esterase-like activity of the antibody-containing site? journal, March 1980

A large increase in enzyme–substrate affinity by protein engineering journal, January 1984

Linkage of cytotoxic agents to immunoglobulins journal, January 1983

Condensation of tetraaldehydes with pyrrole. Direct synthesis of capped porphyrins journal, January 1975

A New Enzyme Containing a Synthetically Formed Active Site. Thiol-Subtilisin 1 journal, July 1966

Selective transamination and optical induction by a .beta.-cyclodextrin-pyridoxamine artificial enzyme journal, January 1980

The interplay between chemistry and biology in the design of enzymatic catalysts journal, April 1988

Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Kinetics of labeling and isolation of a labeled peptide journal, March 1970

Eine über Antikörper gesteuerte Redoxreaktion journal, September 1988

Affinity labeling and cross-linking of the heavy and light chains of a myeloma protein with anti-2,4-dinitrophenol activity journal, August 1971

Antibody Catalysis by Transition State Stabilization
journal, January 1987

Designer catalytic antibodies
journal, March 1989

Catalysis of concerted reactions by antibodies: the Claisen rearrangement.
journal, July 1988

Transaminations by pyridoxamine selectively attached at C-3 in .beta.-cyclodextrin
journal, March 1983

Principles of antibody catalysis
journal, October 1988

Antibody-enzyme analogy. Characterization of antibodies to phosphopyridoxyltyrosine derivatives
journal, February 1975

Engineering antibody affinity and specificity
journal, January 1988

A-(modified B6)-B-[.omega.-amino(ethylamino)]-.beta.-cyclodextrin as an artificial B6 enzyme for chiral aminotransfer reaction
journal, September 1985

Intramolecular general base-acid catalysis in transaminations catalyzed by pyridoxamine enzyme analogs
journal, March 1983

Induction of an antibody that catalyzes the hydrolysis of an amide bond
journal, September 1988

Catalytic antibodies
journal, April 1987

Host-guest complexation. 31. A transacylase partial mimic
journal, August 1984

Catalysis and chiral recognition through designed complexation of transition states in transacylations of amino ester salts
journal, February 1976

Molecular catalysis: enhanced rates of thiolysis with high structural and chiral recognition in complexes of a reactive macrocyclic receptor molecule
journal, January 1978

Artificial enzymes
journal, November 1982

Antibody catalysis approaching the activity of enzymes
journal, March 1988

Generation of a hybrid sequence-specific single-stranded deoxyribonuclease
journal, December 1987

A stereospecific cyclization catalyzed by an antibody
journal, August 1987

The conversion of serine at the active site of subtilisin to cysteine: a "chemical mutation".
journal, November 1966

Cyclodextrin catalysis as a model for enzyme action
journal, March 1982

Antibody catalysis of bimolecular amide formation
journal, July 1988

Chemical mutation of enzyme active sites
journal, November 1984

Photosensitized cleavage of a thymine dimer by an antibody
journal, November 1988

Purification and properties of thiol beta-lactamase. A mutant of pBR322 beta-lactamase in which the active site serine has been replaced with cysteine.
journal, April 1984

An antibody-catalyzed Claisen rearrangement
journal, July 1988

Synthesis of the Myoglobin Active Site
journal, September 1973

Oligonucleotide-directed mutagenesis as a general and powerful method for studies of protein function.
journal, November 1982

Synthetic models for the oxygen-binding hemoproteins
journal, July 1977

Catalytic antibodies
journal, December 1986

Directed mutagenesis of the redox-active disulfide in the flavoenzyme mercuric ion reductase
journal, November 1985

Introduction of nucleophiles and spectroscopic probes into antibody combining sites
journal, November 1988

Selective chemical catalysis by an antibody
journal, December 1986

Localization of affinity-labeled residues on the heavy and light chain of two myeloma proteins with anti-hapten activity
journal, June 1972

Redesigning trypsin: alteration of substrate specificity
journal, April 1985

Monoclonal immunoglobulin G augments hydrolysis of an ester of the homologous hapten: An esterase-like activity of the antibody-containing site?
journal, March 1980

A large increase in enzyme–substrate affinity by protein engineering
journal, January 1984

Linkage of cytotoxic agents to immunoglobulins
journal, January 1983

Condensation of tetraaldehydes with pyrrole. Direct synthesis of capped porphyrins
journal, January 1975

A New Enzyme Containing a Synthetically Formed Active Site. Thiol-Subtilisin ¹
journal, July 1966

Selective transamination and optical induction by a .beta.-cyclodextrin-pyridoxamine artificial enzyme
journal, January 1980

The interplay between chemistry and biology in the design of enzymatic catalysts
journal, April 1988

Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Kinetics of labeling and isolation of a labeled peptide
journal, March 1970

Eine über Antikörper gesteuerte Redoxreaktion
journal, September 1988

Affinity labeling and cross-linking of the heavy and light chains of a myeloma protein with anti-2,4-dinitrophenol activity
journal, August 1971