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Title: Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use

Patent ·
OSTI ID:868004
 [1];  [2];  [2]
  1. Danville, CA
  2. Livermore, CA
+ Show Author Affiliations

Monoclonal antibodies are described which have specific affinities for halogenated nucleoside analogs and are preferentially selective for one particular halogen. Such antibodies, when incorporated into immunochemical reagents, may be used to identify and independently quantify the cell division character of more than one population or subpopulation in flow cytometric measurements. Independent assessment of division activity in cell sub-populations facilitates selection of appropriate time and dose for administration of anti-proliferative agents. The hybridomas which secrete halogen selective antibodies and the method of making them are described.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
DOE Contract Number:
W-7405-ENG-48
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 5053336
OSTI ID:
868004
Country of Publication:
United States
Language:
English

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Related Subjects

monoclonal
antibodies
separate
detection
halodeoxyuridines
method
described
specific
affinities
halogenated
nucleoside
analogs
preferentially
selective
particular
halogen
incorporated
immunochemical
reagents
identify
independently
quantify
cell
division
character
population
subpopulation
flow
cytometric
measurements
independent
assessment
activity
sub-populations
facilitates
selection
appropriate
time
dose
administration
anti-proliferative
agents
hybridomas
secrete
monoclonal antibodies
flow cytometric
separate detection
appropriate time
nucleoside analog
chemical reagent
cytometric measurement
chemical reagents
nucleoside analogs
/530/435/