Multiplexed electronically programmable multimode ionization detector for chromatography

Patent · Sun Jan 01 00:00:00 EST 1989

OSTI ID:867168

Wise, Marcus B ^[1]; Buchanan, Michelle V ^[2]

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1. Kingston, TN
2. Knoxville, TN

Method and apparatus for detecting and differentiating organic compounds based on their electron affinity. An electron capture detector cell (ECD) is operated in a plurality of multiplexed electroncially programmable operating modes to alter the detector response during a single sampling cycle to acquire multiple simultaneous chromatograms corresponding to each of the different operating modes. The cell is held at a constant subatmospheric pressure while the electron collection bias voltage applied to the cell is modulated electronically to allow acquisition of multiple chromatograms for a single sample elution from a chromatograph representing three distinctly different response modes. A system is provided which automatically controls the programmed application of bias pulses at different intervals and/or amplitudes to switch the detector from an ionization mode to the electron capture mode and various degrees therebetween to provide an improved means of tuning an ECD for multimode detection and improved specificity.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4879472
• OSTI ID: 867168
• Country of Publication: United States
• Language: English

Related Subjects

multiplexed
electronically
programmable
multimode
ionization
detector
chromatography
method
apparatus
detecting
differentiating
organic
compounds
based
electron
affinity
capture
cell
ecd
operated
plurality
electroncially
operating
modes
alter
response
single
sampling
cycle
acquire
multiple
simultaneous
chromatograms
corresponding
held
constant
subatmospheric
pressure
collection
bias
voltage
applied
modulated
allow
acquisition
sample
elution
chromatograph
representing
distinctly
provided
automatically
controls
programmed
application
pulses
intervals
amplitudes
switch
mode
various
degrees
therebetween
provide
improved
means
tuning
detection
specificity
voltage applied
organic compound
organic compounds
atmospheric pressure
bias voltage
ionization detector
subatmospheric pressure
electron affinity
electron capture
automatically control
modulated electron
operating modes
modulated electronic
detector cell
ionization mode
compounds based
operating mode
capture detector
differentiating organic
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