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Title: No-carrier-added [1.sup.11 c]putrescine

Abstract

The invention relates to a new radiolabeled imaging agent, no-carrier-added [1-.sup.11 C]putrescine, and to the use of this very pure material as a radiotracer with positron emission tomography for imaging brain tumors. The invention further relates to the synthesis of no-carrier-added [1-.sup.11 C]putrescine based on the Michael addition of potassium .sup.11 C-labeled cyanide to acrylonitrile followed by reduction of the .sup.11 C-labeled dinitrile. The new method is rapid and efficient and provides radiotracer with a specific activity greater than 1.4 curies per millimol and in a purity greater than 95%.

Inventors:
 [1];  [2];  [3]
  1. (Baltimore, MD)
  2. (Bellport, NY)
  3. (Setauket, NY)
Publication Date:
Research Org.:
ASSOC UNIVERSITIES INC
OSTI Identifier:
867138
Patent Number(s):
US 4874600
Assignee:
United States of America as Represented by United States (Washington, DC) BNL
DOE Contract Number:
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
no-carrier-added; 11; putrescine; relates; radiolabeled; imaging; agent; 1-; pure; material; radiotracer; positron; emission; tomography; brain; tumors; synthesis; based; michael; addition; potassium; c-labeled; cyanide; acrylonitrile; followed; reduction; dinitrile; method; rapid; efficient; provides; specific; activity; curies; millimol; purity; 95; emission tomography; positron emission; specific activity; imaging agent; pure material; brain tumors; /424/999/

Citation Formats

McPherson, Daniel W., Fowler, Joanna S., and Wolf, Alfred P. No-carrier-added [1.sup.11 c]putrescine. United States: N. p., 1989. Web.
McPherson, Daniel W., Fowler, Joanna S., & Wolf, Alfred P. No-carrier-added [1.sup.11 c]putrescine. United States.
McPherson, Daniel W., Fowler, Joanna S., and Wolf, Alfred P. Sun . "No-carrier-added [1.sup.11 c]putrescine". United States. doi:. https://www.osti.gov/servlets/purl/867138.
@article{osti_867138,
title = {No-carrier-added [1.sup.11 c]putrescine},
author = {McPherson, Daniel W. and Fowler, Joanna S. and Wolf, Alfred P.},
abstractNote = {The invention relates to a new radiolabeled imaging agent, no-carrier-added [1-.sup.11 C]putrescine, and to the use of this very pure material as a radiotracer with positron emission tomography for imaging brain tumors. The invention further relates to the synthesis of no-carrier-added [1-.sup.11 C]putrescine based on the Michael addition of potassium .sup.11 C-labeled cyanide to acrylonitrile followed by reduction of the .sup.11 C-labeled dinitrile. The new method is rapid and efficient and provides radiotracer with a specific activity greater than 1.4 curies per millimol and in a purity greater than 95%.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1989},
month = {Sun Jan 01 00:00:00 EST 1989}
}

Patent:

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