No-carrier-added [1.sup.11 c]putrescine

Patent · 31 December 1988

OSTI ID:867138

McPherson, Daniel W ^[1]; Fowler, Joanna S ^[2]; Wolf, Alfred P ^[3]

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1. Baltimore, MD
2. Bellport, NY
3. Setauket, NY

The invention relates to a new radiolabeled imaging agent, no-carrier-added [1-.sup.11 C]putrescine, and to the use of this very pure material as a radiotracer with positron emission tomography for imaging brain tumors. The invention further relates to the synthesis of no-carrier-added [1-.sup.11 C]putrescine based on the Michael addition of potassium .sup.11 C-labeled cyanide to acrylonitrile followed by reduction of the .sup.11 C-labeled dinitrile. The new method is rapid and efficient and provides radiotracer with a specific activity greater than 1.4 curies per millimol and in a purity greater than 95%.

• Research Organization: ASSOC UNIVERSITIES INC
• DOE Contract Number: AC02-76CH00016
• Assignee: United States of America as Represented by United States (Washington, DC)
• Patent Number(s): US 4874600
• OSTI ID: 867138
• Country of Publication: United States
• Language: English

Related Subjects

/424/999/
1-
11
95
acrylonitrile
activity
addition
agent
based
brain
brain tumors
c-labeled
curies
cyanide
dinitrile
efficient
emission
emission tomography
followed
imaging
imaging agent
material
method
michael
millimol
no-carrier-added
positron
positron emission
potassium
provides
pure
pure material
purity
putrescine
radiolabeled
radiotracer
rapid
reduction
relates
specific
specific activity
synthesis
tomography
tumors