Enzymatic temperature change indicator

Patent · Sat Jan 21 00:00:00 EST 1989

OSTI ID:866939

Klibanov, Alexander M ^[1]; Dordick, Jonathan S ^[2]

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1. Newton, MA
2. Iowa City, IA

A temperature change indicator is described which is composed of an enzyme and a substrate for that enzyme suspended in a solid organic solvent or mixture of solvents as a support medium. The organic solvent or solvents are chosen so as to melt at a specific temperature or in a specific temperature range. When the temperature of the indicator is elevated above the chosen, or critical temperature, the solid organic solvent support will melt, and the enzymatic reaction will occur, producing a visually detectable product which is stable to further temperature variation.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• Assignee: Massachusetts Industry of Technology (Cambridge, MA)
• Patent Number(s): US 4826762
• Application Number: 06/459,787
• OSTI ID: 866939
• Country of Publication: United States
• Language: English

Related Subjects

enzymatic
temperature
change
indicator
described
composed
enzyme
substrate
suspended
solid
organic
solvent
mixture
solvents
support
medium
chosen
melt
specific
range
elevated
critical
reaction
occur
producing
visually
detectable
product
stable
variation
enzymatic reaction
temperature change
solid organic
critical temperature
temperature range
organic solvent
temperature variation
change indicator
support medium
/435/116/374/426/