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Title: Enzymatic temperature change indicator

Abstract

A temperature change indicator is described which is composed of an enzyme and a substrate for that enzyme suspended in a solid organic solvent or mixture of solvents as a support medium. The organic solvent or solvents are chosen so as to melt at a specific temperature or in a specific temperature range. When the temperature of the indicator is elevated above the chosen, or critical temperature, the solid organic solvent support will melt, and the enzymatic reaction will occur, producing a visually detectable product which is stable to further temperature variation.

Inventors:
 [1];  [2]
  1. (Newton, MA)
  2. (Iowa City, IA)
Publication Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN
OSTI Identifier:
866939
Patent Number(s):
US 4826762
Application Number:
06/459,787
Assignee:
Massachusetts Industry of Technology (Cambridge, MA) ORNL
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
enzymatic; temperature; change; indicator; described; composed; enzyme; substrate; suspended; solid; organic; solvent; mixture; solvents; support; medium; chosen; melt; specific; range; elevated; critical; reaction; occur; producing; visually; detectable; product; stable; variation; enzymatic reaction; temperature change; solid organic; critical temperature; temperature range; organic solvent; temperature variation; change indicator; support medium; /435/116/374/426/

Citation Formats

Klibanov, Alexander M., and Dordick, Jonathan S.. Enzymatic temperature change indicator. United States: N. p., 1989. Web.
Klibanov, Alexander M., & Dordick, Jonathan S.. Enzymatic temperature change indicator. United States.
Klibanov, Alexander M., and Dordick, Jonathan S.. Sat . "Enzymatic temperature change indicator". United States. https://www.osti.gov/servlets/purl/866939.
@article{osti_866939,
title = {Enzymatic temperature change indicator},
author = {Klibanov, Alexander M. and Dordick, Jonathan S.},
abstractNote = {A temperature change indicator is described which is composed of an enzyme and a substrate for that enzyme suspended in a solid organic solvent or mixture of solvents as a support medium. The organic solvent or solvents are chosen so as to melt at a specific temperature or in a specific temperature range. When the temperature of the indicator is elevated above the chosen, or critical temperature, the solid organic solvent support will melt, and the enzymatic reaction will occur, producing a visually detectable product which is stable to further temperature variation.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1989},
month = {1}
}

Patent:

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