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Title: Alkyl phospholipid antihypertensive agents in method of lowering blood pressure

Abstract

The composition of this invention is 1-O-alkyl-2-acetoyl-sn-glycero-3-phosphocholine, having the ionic structural formula; ##STR1## wherein R is saturated alkyl having 9-21 carbon atoms, or salts or hydrates of the composition. Preferably R has 13-19 carbon atoms and most preferably R has 15 carbon atoms. The composition of this invention is useful for reducing hypertension in warm-blooded animals, including humans, when administered either orally or by injection or innoculation, e.g., intravenous injection. The composition can be prepared from naturally occurring lipids or synthetically from commercially available material.

Inventors:
 [1];  [1];  [2];  [3];  [2]
  1. (Oak Ridge, TN)
  2. (Memphis, TN)
  3. (late of Memphis, TN)
Publication Date:
Research Org.:
OAK RIDGE ASSOC UNIV
OSTI Identifier:
866503
Patent Number(s):
US 4725588
Assignee:
United States of America as represented by United States (Washington, DC) ORNL
DOE Contract Number:  
AC05-76OR00033
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
alkyl; phospholipid; antihypertensive; agents; method; lowering; blood; pressure; composition; 1-o-alkyl-2-acetoyl-sn-glycero-3-phosphocholine; ionic; structural; formula; str1; saturated; 9-21; carbon; atoms; salts; hydrates; preferably; 13-19; 15; useful; reducing; hypertension; warm-blooded; animals; including; humans; administered; orally; injection; innoculation; intravenous; prepared; naturally; occurring; lipids; synthetically; commercially; available; material; naturally occurring; carbon atoms; commercially available; carbon atom; warm-blooded animals; including human; structural form; blood pressure; /514/999/

Citation Formats

Snyder, Fred L., Blank, Merle L., Muirhead, Ernest E., Leach, deceased, Byron E., and Byers, Lawrence W.. Alkyl phospholipid antihypertensive agents in method of lowering blood pressure. United States: N. p., 1988. Web.
Snyder, Fred L., Blank, Merle L., Muirhead, Ernest E., Leach, deceased, Byron E., & Byers, Lawrence W.. Alkyl phospholipid antihypertensive agents in method of lowering blood pressure. United States.
Snyder, Fred L., Blank, Merle L., Muirhead, Ernest E., Leach, deceased, Byron E., and Byers, Lawrence W.. Fri . "Alkyl phospholipid antihypertensive agents in method of lowering blood pressure". United States. https://www.osti.gov/servlets/purl/866503.
@article{osti_866503,
title = {Alkyl phospholipid antihypertensive agents in method of lowering blood pressure},
author = {Snyder, Fred L. and Blank, Merle L. and Muirhead, Ernest E. and Leach, deceased, Byron E. and Byers, Lawrence W.},
abstractNote = {The composition of this invention is 1-O-alkyl-2-acetoyl-sn-glycero-3-phosphocholine, having the ionic structural formula; ##STR1## wherein R is saturated alkyl having 9-21 carbon atoms, or salts or hydrates of the composition. Preferably R has 13-19 carbon atoms and most preferably R has 15 carbon atoms. The composition of this invention is useful for reducing hypertension in warm-blooded animals, including humans, when administered either orally or by injection or innoculation, e.g., intravenous injection. The composition can be prepared from naturally occurring lipids or synthetically from commercially available material.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1988},
month = {Fri Jan 01 00:00:00 EST 1988}
}

Patent:

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