Alkyl phospholipid antihypertensive agents in method of lowering blood pressure

Patent · Fri Jan 01 00:00:00 EST 1988

OSTI ID:866503

Snyder, Fred L ^[1]; Blank, Merle L ^[1]; Muirhead, Ernest E ^[2]; Byers, Lawrence W ^[2]

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1. Oak Ridge, TN
2. Memphis, TN

The composition of this invention is 1-O-alkyl-2-acetoyl-sn-glycero-3-phosphocholine, having the ionic structural formula; ##STR1## wherein R is saturated alkyl having 9-21 carbon atoms, or salts or hydrates of the composition. Preferably R has 13-19 carbon atoms and most preferably R has 15 carbon atoms. The composition of this invention is useful for reducing hypertension in warm-blooded animals, including humans, when administered either orally or by injection or innoculation, e.g., intravenous injection. The composition can be prepared from naturally occurring lipids or synthetically from commercially available material.

• Research Organization: Oak Ridge Associated Universities (ORAU), Oak Ridge, TN (United States)
• DOE Contract Number: AC05-76OR00033
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4725588
• OSTI ID: 866503
• Country of Publication: United States
• Language: English

Related Subjects

alkyl
phospholipid
antihypertensive
agents
method
lowering
blood
pressure
composition
1-o-alkyl-2-acetoyl-sn-glycero-3-phosphocholine
ionic
structural
formula
str1
saturated
9-21
carbon
atoms
salts
hydrates
preferably
13-19
15
useful
reducing
hypertension
warm-blooded
animals
including
humans
administered
orally
injection
innoculation
intravenous
prepared
naturally
occurring
lipids
synthetically
commercially
available
material
naturally occurring
carbon atoms
commercially available
carbon atom
warm-blooded animals
including human
structural form
blood pressure
/514/999/