Method and apparatus for molecular imaging using X-rays at resonance wavelengths

Patent · Tue Jan 01 00:00:00 EST 1985

OSTI ID:865560

Chapline, Jr., George F. ^[1]

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1. (Alamo, CA)

Holographic X-ray images are produced representing the molecular structure of a microscopic object, such as a living cell, by directing a beam of coherent X-rays upon the object to produce scattering of the X-rays by the object, producing interference on a recording medium between the scattered X-rays from the object and unscattered coherent X-rays and thereby producing holograms on the recording surface, and establishing the wavelength of the coherent X-rays to correspond with a molecular resonance of a constituent of such object and thereby greatly improving the contrast, sensitivity and resolution of the holograms as representations of molecular structures involving such constituent. For example, the coherent X-rays may be adjusted to the molecular resonant absorption line of nitrogen at about 401.3 eV to produce holographic images featuring molecular structures involving nitrogen.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4536883
• OSTI ID: 865560
• Country of Publication: United States
• Language: English

Related Subjects

method
apparatus
molecular
imaging
x-rays
resonance
wavelengths
holographic
x-ray
images
produced
representing
structure
microscopic
living
cell
directing
beam
coherent
produce
scattering
producing
interference
recording
medium
scattered
unscattered
holograms
surface
establishing
wavelength
correspond
constituent
greatly
improving
contrast
sensitivity
resolution
representations
structures
involving
example
adjusted
resonant
absorption
line
nitrogen
401
featuring
x-ray image
coherent x-rays
absorption line
molecular structure
recording medium
holographic image
holographic images
scattered x-ray
resonance wavelengths
resonance wavelength
greatly improving
x-ray images
/378/