Low toxicity method of inhibiting sickling of sickle erythrocytes
Patent
·
OSTI ID:862920
- Orinda, CA
- Oakland, CA
A low toxicity method of inhibiting sickling of sickle erythrocytes which comprises intermixing the erythrocytes with an effective anti-sickling amount of a water-soluble imidoester of the formula RC(=NH)OR' wherein R is an alkyl group of 1 - 8 carbon atoms, particularly 1 - 4 carbon atoms, and R' is an alkyl group of 1 - 4 carbon atoms, specifically methyl or ethyl acetimidate.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA
- DOE Contract Number:
- W-7405-ENG-48
- Assignee:
- United States of America as represented by United States Energy (Washington, DC)
- Patent Number(s):
- US 4048325
- OSTI ID:
- 862920
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
/514/435/
acetimidate
alkyl
amount
anti-sickling
atoms
carbon
carbon atom
carbon atoms
comprises
effective
erythrocytes
ethyl
formula
imidoester
inhibiting
inhibiting sickling
intermixing
method
methyl
nh
particularly
sickle
sickle erythrocytes
sickling
specifically
toxicity
toxicity method
water-soluble
acetimidate
alkyl
amount
anti-sickling
atoms
carbon
carbon atom
carbon atoms
comprises
effective
erythrocytes
ethyl
formula
imidoester
inhibiting
inhibiting sickling
intermixing
method
methyl
nh
particularly
sickle
sickle erythrocytes
sickling
specifically
toxicity
toxicity method
water-soluble