Liposome-encapsulated actinomycin for cancer chemotherapy
Patent
·
OSTI ID:862712
- Downers Grove, IL
An improved method is provided for chemotherapy of malignant tumors by injection of antitumor drugs. The antitumor drug is encapsulated within liposomes and the liposomes containing the encapsulated drug are injected into the body. The encapsulated drug penetrates into the tumor cells where the drug is slowly released and induces degeneration and death of the tumor cells, while any toxicity to the host body is reduced. Liposome encapsulation of actinomycin D has been found to be particularly effective in treating cancerous abdominal tumors, while drastically reducing the toxicity of actinomycin D to the host.
- Research Organization:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- DOE Contract Number:
- W-31109-ENG-38
- Assignee:
- United States of America as represented by United States Energy (Washington, DC)
- Patent Number(s):
- US 3993754
- OSTI ID:
- 862712
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
liposome-encapsulated
actinomycin
cancer
chemotherapy
improved
method
provided
malignant
tumors
injection
antitumor
drugs
drug
encapsulated
liposomes
containing
injected
penetrates
tumor
cells
slowly
released
induces
degeneration
death
toxicity
host
reduced
liposome
encapsulation
found
particularly
effective
treating
cancerous
abdominal
drastically
reducing
improved method
tumor cells
particularly effective
antitumor drug
malignant tumors
liposomes containing
liposome encapsulation
/514/424/
actinomycin
cancer
chemotherapy
improved
method
provided
malignant
tumors
injection
antitumor
drugs
drug
encapsulated
liposomes
containing
injected
penetrates
tumor
cells
slowly
released
induces
degeneration
death
toxicity
host
reduced
liposome
encapsulation
found
particularly
effective
treating
cancerous
abdominal
drastically
reducing
improved method
tumor cells
particularly effective
antitumor drug
malignant tumors
liposomes containing
liposome encapsulation
/514/424/