Liposome-encapsulated actinomycin for cancer chemotherapy
Patent
·
OSTI ID:862712
- Downers Grove, IL
An improved method is provided for chemotherapy of malignant tumors by injection of antitumor drugs. The antitumor drug is encapsulated within liposomes and the liposomes containing the encapsulated drug are injected into the body. The encapsulated drug penetrates into the tumor cells where the drug is slowly released and induces degeneration and death of the tumor cells, while any toxicity to the host body is reduced. Liposome encapsulation of actinomycin D has been found to be particularly effective in treating cancerous abdominal tumors, while drastically reducing the toxicity of actinomycin D to the host.
- Research Organization:
- Argonne National Laboratory (ANL), Argonne, IL
- DOE Contract Number:
- W-31109-ENG-38
- Assignee:
- United States of America as represented by United States Energy (Washington, DC)
- Patent Number(s):
- US 3993754
- OSTI ID:
- 862712
- Country of Publication:
- United States
- Language:
- English
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abdominal
actinomycin
antitumor
antitumor drug
cancer
cancerous
cells
chemotherapy
containing
death
degeneration
drastically
drug
drugs
effective
encapsulated
encapsulation
found
host
improved
improved method
induces
injected
injection
liposome
liposome encapsulation
liposome-encapsulated
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malignant
malignant tumors
method
particularly
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penetrates
provided
reduced
reducing
released
slowly
toxicity
treating
tumor
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abdominal
actinomycin
antitumor
antitumor drug
cancer
cancerous
cells
chemotherapy
containing
death
degeneration
drastically
drug
drugs
effective
encapsulated
encapsulation
found
host
improved
improved method
induces
injected
injection
liposome
liposome encapsulation
liposome-encapsulated
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liposomes containing
malignant
malignant tumors
method
particularly
particularly effective
penetrates
provided
reduced
reducing
released
slowly
toxicity
treating
tumor
tumor cells
tumors