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Title: Signal Transduction Pathways that Regulate CAB Gene Expression

Abstract

The process of chloroplast differentiation, involves the coordinate regulation of many nuclear and chloroplast genes. The cues for the initiation of this developmental program are both extrinsic (e.g., light) and intrinsic (cell-type and plastid signals). During this project period, we utilized a molecular genetic approach to select for Arabidopsis mutants that did not respond properly to environmental light conditions, as well as mutants that were unable to perceive plastid damage. These latter mutants, called gun mutants, define two retrograde signaling pathways that regulate nuclear gene expression in response to chloroplasts. A major finding was to identify a signal from chloroplasts that regulates nuclear gene transcription. This signal is the build-up of Mg-Protoporphyrin IX, a key intermediate of the chlorophyll biosynthetic pathway. The signaling pathways downstream of this signal are currently being studied. Completion of this project has provided an increased understanding of the input signals and retrograde signaling pathways that control nuclear gene expression in response to the functional state of chloroplasts. These studies should ultimately influence our abilities to manipulate plant growth and development, and will aid in the understanding of the developmental control of photosynthesis.

Authors:
Publication Date:
Research Org.:
The Salk Institute for Biological Studies, La Jolla, California
Sponsoring Org.:
SC-17
OSTI Identifier:
862356
DOE Contract Number:  
FG03-89ER13993
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ARABIDOPSIS; CHLOROPHYLL; CHLOROPLASTS; FUNCTIONALS; GENES; GENETICS; MUTANTS; PHOTOSYNTHESIS; PLANT GROWTH; REGULATIONS; TRANSCRIPTION; Chloroplast development, photosynthesis, plants

Citation Formats

Chory, Joanne. Signal Transduction Pathways that Regulate CAB Gene Expression. United States: N. p., 2006. Web. doi:10.2172/862356.
Chory, Joanne. Signal Transduction Pathways that Regulate CAB Gene Expression. United States. doi:10.2172/862356.
Chory, Joanne. Mon . "Signal Transduction Pathways that Regulate CAB Gene Expression". United States. doi:10.2172/862356. https://www.osti.gov/servlets/purl/862356.
@article{osti_862356,
title = {Signal Transduction Pathways that Regulate CAB Gene Expression},
author = {Chory, Joanne},
abstractNote = {The process of chloroplast differentiation, involves the coordinate regulation of many nuclear and chloroplast genes. The cues for the initiation of this developmental program are both extrinsic (e.g., light) and intrinsic (cell-type and plastid signals). During this project period, we utilized a molecular genetic approach to select for Arabidopsis mutants that did not respond properly to environmental light conditions, as well as mutants that were unable to perceive plastid damage. These latter mutants, called gun mutants, define two retrograde signaling pathways that regulate nuclear gene expression in response to chloroplasts. A major finding was to identify a signal from chloroplasts that regulates nuclear gene transcription. This signal is the build-up of Mg-Protoporphyrin IX, a key intermediate of the chlorophyll biosynthetic pathway. The signaling pathways downstream of this signal are currently being studied. Completion of this project has provided an increased understanding of the input signals and retrograde signaling pathways that control nuclear gene expression in response to the functional state of chloroplasts. These studies should ultimately influence our abilities to manipulate plant growth and development, and will aid in the understanding of the developmental control of photosynthesis.},
doi = {10.2172/862356},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 16 00:00:00 EST 2006},
month = {Mon Jan 16 00:00:00 EST 2006}
}

Technical Report:

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