Semiconductor Nanocrystals for Biological Imaging
Conventional organic fluorophores suffer from poor photo stability, narrow absorption spectra and broad emission feature. Semiconductor nanocrystals, on the other hand, are highly photo-stable with broad absorption spectra and narrow size-tunable emission spectra. Recent advances in the synthesis of these materials have resulted in bright, sensitive, extremely photo-stable and biocompatible semiconductor fluorophores. Commercial availability facilitates their application in a variety of unprecedented biological experiments, including multiplexed cellular imaging, long-term in vitro and in vivo labeling, deep tissue structure mapping and single particle investigation of dynamic cellular processes. Semiconductor nanocrystals are one of the first examples of nanotechnology enabling a new class of biomedical applications.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE; National Institutes of Health. National Center forResearch Resources Agreement 0980GCF709, Department of Defense. BreastCancer Research progam DAMD17-03-1-9637, US Defense Advanced ResearchProject Agency. Air Force Office of Scientific Research. DefenseUniversity Research Initiative on Nanotechnology Program GrantF49620-01-1-0474
- DOE Contract Number:
- DE-AC02-05CH11231; NIH:0980GCD709
- OSTI ID:
- 861264
- Report Number(s):
- LBNL-57928; R&D Project: M50013; BnR: 600305000; TRN: US200601%%754
- Journal Information:
- Current Opinion in Neurobiology, Vol. 15, Issue 5; Related Information: Journal Publication Date: 10/2005
- Country of Publication:
- United States
- Language:
- English
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