Oxygen chemistry in biology: Vibrational spectroscopy, stable isotopes, and future applications

Conference · Thu Dec 01 00:00:00 EST 1994

OSTI ID:84793

Babcock, G T ^[1]

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1. Michigan State Univ., East Lansing, MI (United States)

Dioxygen is an ideally suited substrate for enzymatic manipulation in oxidation-reduction chemistry and in substrate transformation. It is a powerful oxidant with a midpoint potential of 0.815 at neutral pH; at the same time, however, it exists in a triplet state in its most stable electronic configuration. This latter property confers kinetic inertness as a result of spin-conservation restrictions on reaction chemistry. If these restrictions can be overcome and controlled, dioxygen`s high redox potential can be used to maximize efficiency in free-energy conversion processes and to effect activation of relatively inert substrates.

• Research Organization: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
• OSTI ID: 84793
• Report Number(s): LA-12893-C; CONF-9403228-; ON: DE95012795; CNN: Grant NIH GM25480; TRN: 95:004732-0002
• Resource Relation: Conference: Stable isotope applications in biomolecular structure and mechanisms, Santa Fe, NM (United States), 27-31 Mar 1994; Other Information: PBD: Dec 1994; Related Information: Is Part Of Stable isotope applications in biomolecular structure and mechanisms. A meeting to bring together producers and users of stable-isotope-labeled compounds to assess current and future needs; Trewhella, J.; Cross, T.A.; Unkefer, C.J. [eds.]; PB: 382 p.
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
40 CHEMISTRY
OXIDIZERS
REDOX POTENTIAL
REDOX REACTIONS
OXYGEN ISOTOPES
SPECTROSCOPY
MAGNETIC RESONANCE
CONFIGURATION
FREE ENERGY
OXIDATION
STABLE ISOTOPES
SUBSTRATES
ISOTOPE APPLICATIONS
ENZYME ACTIVITY