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Title: Motifs, modules and games in bacteria

Abstract

Global explorations of regulatory network dynamics, organization and evolution have become tractable thanks to high-throughput sequencing and molecular measurement of bacterial physiology. From these, a nascent conceptual framework is developing, that views the principles of regulation in term of motifs, modules and games. Motifs are small, repeated, and conserved biological units ranging from molecular domains to small reaction networks. They are arranged into functional modules, genetically dissectible cellular functions such as the cell cycle, or different stress responses. The dynamical functioning of modules defines the organism's strategy to survive in a game, pitting cell against cell, and cell against environment. Placing pathway structure and dynamics into an evolutionary context begins to allow discrimination between those physical and molecular features that particularize a species to its surroundings, and those that provide core physiological function. This approach promises to generate a higher level understanding of cellular design, pathway evolution and cellular bioengineering.

Authors:
;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
842252
Report Number(s):
LBNL-53696
R&D Project: VGTLAA; TRN: US200516%%144
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Journal Article
Journal Name:
Current Opinions in Microbiology
Additional Journal Information:
Journal Volume: 6; Journal Issue: 2; Other Information: Journal Publication Date: Apr 2003
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BACTERIA; CELL CYCLE; PHYSIOLOGY; MOLECULAR STRUCTURE; BIOLOGICAL EVOLUTION; BIOLOGICAL FUNCTIONS

Citation Formats

Wolf, Denise M., and Arkin, Adam P. Motifs, modules and games in bacteria. United States: N. p., 2003. Web. doi:10.1016/S1369-5274(03)00033-X.
Wolf, Denise M., & Arkin, Adam P. Motifs, modules and games in bacteria. United States. doi:10.1016/S1369-5274(03)00033-X.
Wolf, Denise M., and Arkin, Adam P. Tue . "Motifs, modules and games in bacteria". United States. doi:10.1016/S1369-5274(03)00033-X.
@article{osti_842252,
title = {Motifs, modules and games in bacteria},
author = {Wolf, Denise M. and Arkin, Adam P.},
abstractNote = {Global explorations of regulatory network dynamics, organization and evolution have become tractable thanks to high-throughput sequencing and molecular measurement of bacterial physiology. From these, a nascent conceptual framework is developing, that views the principles of regulation in term of motifs, modules and games. Motifs are small, repeated, and conserved biological units ranging from molecular domains to small reaction networks. They are arranged into functional modules, genetically dissectible cellular functions such as the cell cycle, or different stress responses. The dynamical functioning of modules defines the organism's strategy to survive in a game, pitting cell against cell, and cell against environment. Placing pathway structure and dynamics into an evolutionary context begins to allow discrimination between those physical and molecular features that particularize a species to its surroundings, and those that provide core physiological function. This approach promises to generate a higher level understanding of cellular design, pathway evolution and cellular bioengineering.},
doi = {10.1016/S1369-5274(03)00033-X},
journal = {Current Opinions in Microbiology},
number = 2,
volume = 6,
place = {United States},
year = {2003},
month = {4}
}