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Title: Adaptive response against spontaneous neoplastic transformation induced by low dose ionizing radiation

Abstract

This project is being conducted to ascertain the shape of the dose response curve for neoplastic transformation in vitro over the dose range 0.0 to 10 cGy, and how this depends on radiation quality and dose fractionation. Preliminary data already have indicated that at a dose of 1 cGy the induced transformation frequency is less than the spontaneous transformation frequency. The results will be compared with animal and human epidemiological data on the induction of cancer by low doses of radiation. This will hopefully allow for a more informed estimation of the risk of cancer induction at low doses (see Pollycove, 1998; Rossi, 1999).

Authors:
Publication Date:
Research Org.:
University of California Irvine (US)
Sponsoring Org.:
USDOE Office of Environmental Management (EM) (US)
OSTI Identifier:
833309
Report Number(s):
EMSP-69848-2000
R&D Project: EMSP 69848; TRN: US200430%%1417
DOE Contract Number:  
FG07-99ER62876
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: 1 Jun 2000
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ANIMALS; FRACTIONATED IRRADIATION; IN VITRO; INDUCTION; IONIZING RADIATIONS; NEOPLASMS; RADIATION QUALITY; SHAPE; TRANSFORMATIONS

Citation Formats

Redpath, J Leslie. Adaptive response against spontaneous neoplastic transformation induced by low dose ionizing radiation. United States: N. p., 2000. Web. doi:10.2172/833309.
Redpath, J Leslie. Adaptive response against spontaneous neoplastic transformation induced by low dose ionizing radiation. United States. doi:10.2172/833309.
Redpath, J Leslie. Thu . "Adaptive response against spontaneous neoplastic transformation induced by low dose ionizing radiation". United States. doi:10.2172/833309. https://www.osti.gov/servlets/purl/833309.
@article{osti_833309,
title = {Adaptive response against spontaneous neoplastic transformation induced by low dose ionizing radiation},
author = {Redpath, J Leslie},
abstractNote = {This project is being conducted to ascertain the shape of the dose response curve for neoplastic transformation in vitro over the dose range 0.0 to 10 cGy, and how this depends on radiation quality and dose fractionation. Preliminary data already have indicated that at a dose of 1 cGy the induced transformation frequency is less than the spontaneous transformation frequency. The results will be compared with animal and human epidemiological data on the induction of cancer by low doses of radiation. This will hopefully allow for a more informed estimation of the risk of cancer induction at low doses (see Pollycove, 1998; Rossi, 1999).},
doi = {10.2172/833309},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {6}
}

Technical Report:

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