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Title: Human Genetic Marker for Resistance to Radiations and Chemicals

Abstract

The major objective of this project is to understand the genetic basis for resistance of humans to radiations and chemicals. In the fission yeast S. pombe, a gene called rad9 plays a key role in promoting resistance to DNA damaging agents and controlling cell cycle progression after radiation or chemical exposure. This investigation focuses on the characterization of a human homologue of this yeast gene, called HRAD9, with the longterm goal of developing the gene as a genetic marker to predict inherent susceptibility to the deleterious health effects caused by DNA damage. The aims concern a molecular characterization of HRAD9 and determination of its role in mediating the cellular response to radiations and chemicals, as well as its potential role in carcinogenesis.

Authors:
Publication Date:
Research Org.:
Columbia University, New York, NY (US)
Sponsoring Org.:
USDOE Office of Environmental Management (EM) (US)
OSTI Identifier:
827399
Report Number(s):
EMSP-55100-2000
R&D Project: EMSP 55100; TRN: US200425%%640
DOE Contract Number:  
FG07-96ER62309
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: 1 Jun 2000
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 54 ENVIRONMENTAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; CARCINOGENESIS; CELL CYCLE; DNA; DNA DAMAGES; FISSION; GENES; GENETICS; RADIATIONS; YEASTS

Citation Formats

Lieberman, Howard B. Human Genetic Marker for Resistance to Radiations and Chemicals. United States: N. p., 2000. Web. doi:10.2172/827399.
Lieberman, Howard B. Human Genetic Marker for Resistance to Radiations and Chemicals. United States. doi:10.2172/827399.
Lieberman, Howard B. Thu . "Human Genetic Marker for Resistance to Radiations and Chemicals". United States. doi:10.2172/827399. https://www.osti.gov/servlets/purl/827399.
@article{osti_827399,
title = {Human Genetic Marker for Resistance to Radiations and Chemicals},
author = {Lieberman, Howard B},
abstractNote = {The major objective of this project is to understand the genetic basis for resistance of humans to radiations and chemicals. In the fission yeast S. pombe, a gene called rad9 plays a key role in promoting resistance to DNA damaging agents and controlling cell cycle progression after radiation or chemical exposure. This investigation focuses on the characterization of a human homologue of this yeast gene, called HRAD9, with the longterm goal of developing the gene as a genetic marker to predict inherent susceptibility to the deleterious health effects caused by DNA damage. The aims concern a molecular characterization of HRAD9 and determination of its role in mediating the cellular response to radiations and chemicals, as well as its potential role in carcinogenesis.},
doi = {10.2172/827399},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {6}
}

Technical Report:

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