Environmental Analysis of Endocrine Disrupting Effects from Hydrocarbon Contaminants in the Ecosystem
This annual report summarizes the progress of three years of a three-year grant awarded to the Center for Bioenvironmental Research (CBR) at Tulane and Xavier Universities. The objective of this project is to determine how environmental contaminants, namely hydrocarbons, can act as hormones or anti-hormones in different species present in aquatic ecosystems. The three major areas of research include (1) a biotechnology based screening system to identify potential hormone mimics and antagonists; (2) an animal screening system to identify biomarkers of endocrine effects; and (3) a literature review to identify compounds at various DOE sites that are potential endocrine disruptors. Species of particular focus in this study are those which can serve as sentinel species (e.g., amphibians) and, thus, provide early warning signals for more widespread impacts on an ecosystem and its wildlife and human inhabitants. The focus of the literature research was to provide an analysis of the contaminants located on or around various Department of Energy (DOE) sites that are or have the potential to function as endocrine disruptors and to correlate the need for studying endocrine disruptors to DOE's programmatic needs. Previous research within the Center for Bioenvironmental Research at Tulane and Xavier Universities has focused on understanding the effects of environmental agents on the human and wildlife health and disease. In particular this research has focused on how exogenous agents can function to mimic or disrupt normal endocrine signaling, i.e. estrogen, thyroid within various systems from whole animal studies with fish, amphibians and insects to human cancer cell lines. Significant work has focused on the estrogenic and anti-estrogenic action of both synthetic organochlorine chemicals and naturally produced phytochemicals. Recent projects have extended these research objectives to examination of these environmental agents on the symbiotic relationship between nitrogen fixing rhizobial bacteria and leguminous plants. This research will form the foundation for future experiments into the genetic manipulation of plants to potentially promote greater or more specific symbiotic relationships between plant and Rhizobium allowing this biological phenomenon to be used in a greater number of crop types. Future technology developments could include the genetic engineering of crops suitable for in situ vadose zone 2 bioremediation (via microbes) and phytoremediation (through the crop, itself) in contaminated DOE sites.
- Research Organization:
- Tulane University, New Orleans, Louisiana (US)
- Sponsoring Organization:
- USDOE Office of Environmental Management (EM) (US)
- DOE Contract Number:
- FG07-96ER62308
- OSTI ID:
- 827358
- Report Number(s):
- EMSP-55032-2000; R&D Project: EMSP 55032; TRN: US200425%%618
- Resource Relation:
- Other Information: PBD: 1 Jun 2000
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS
AMPHIBIANS
ANIMALS
AQUATIC ECOSYSTEMS
BACTERIA
BIOREMEDIATION
BIOTECHNOLOGY
ECOSYSTEMS
GENETIC ENGINEERING
GENETICS
HORMONES
HYDROCARBONS
INSECTS
NEOPLASMS
NITROGEN
RHIZOBIUM
THYROID