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Title: Mechanism Involved in Trichloroethylene-Induced Liver Cancer: Importance to Environmental Cleanup

Abstract

The objective of this project is to develop critical data for improving risk-based cleanup standards for trichloroethylene (TCE). Importance to DOE. Cleanup costs for chlorinated solvents found on DOE sites are most frequently driven by TCE because it is the most widespread contaminant and is generally present at the highest concentrations. Data that would permit increases in risk-based standards for TCE would reduce complex wide cleanup costs by hundreds of millions of dollars. Current Regulatory Actions that Research will Impact. EPA is currently reviewing its risk assessment for TCE. Richard J. Bull has worked with EPA on this review by writing the mode of action section of their determination. A presentation by James Cogliano of EPA at the 1999 Annual Society of Toxicology Meeting indicates that they have accepted the concept of nonlinear extrapolation for liver tumor induction by TCE. This project will end in FY 1999 with its major technical and policy objectives satisfied.

Authors:
;
Publication Date:
Research Org.:
Pacific Northwest National Lab., Richland, WA (US)
Sponsoring Org.:
USDOE Office of Environmental Management (EM) (US)
OSTI Identifier:
827051
Report Number(s):
EMSP-54684-1999
R&D Project: EMSP 54684; TRN: US200425%%220
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: 1 Jun 1999
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; DOLLARS; EXTRAPOLATION; INDUCTION; LIVER; NEOPLASMS; RISK ASSESSMENT; SOLVENTS; US EPA

Citation Formats

Bull, Richard J., and Thrall, Brian D. Mechanism Involved in Trichloroethylene-Induced Liver Cancer: Importance to Environmental Cleanup. United States: N. p., 1999. Web. doi:10.2172/827051.
Bull, Richard J., & Thrall, Brian D. Mechanism Involved in Trichloroethylene-Induced Liver Cancer: Importance to Environmental Cleanup. United States. doi:10.2172/827051.
Bull, Richard J., and Thrall, Brian D. Tue . "Mechanism Involved in Trichloroethylene-Induced Liver Cancer: Importance to Environmental Cleanup". United States. doi:10.2172/827051. https://www.osti.gov/servlets/purl/827051.
@article{osti_827051,
title = {Mechanism Involved in Trichloroethylene-Induced Liver Cancer: Importance to Environmental Cleanup},
author = {Bull, Richard J. and Thrall, Brian D.},
abstractNote = {The objective of this project is to develop critical data for improving risk-based cleanup standards for trichloroethylene (TCE). Importance to DOE. Cleanup costs for chlorinated solvents found on DOE sites are most frequently driven by TCE because it is the most widespread contaminant and is generally present at the highest concentrations. Data that would permit increases in risk-based standards for TCE would reduce complex wide cleanup costs by hundreds of millions of dollars. Current Regulatory Actions that Research will Impact. EPA is currently reviewing its risk assessment for TCE. Richard J. Bull has worked with EPA on this review by writing the mode of action section of their determination. A presentation by James Cogliano of EPA at the 1999 Annual Society of Toxicology Meeting indicates that they have accepted the concept of nonlinear extrapolation for liver tumor induction by TCE. This project will end in FY 1999 with its major technical and policy objectives satisfied.},
doi = {10.2172/827051},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 01 00:00:00 EDT 1999},
month = {Tue Jun 01 00:00:00 EDT 1999}
}

Technical Report:

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