Analysis and Annotation of Nucleic Acid Sequence
The aims of this project were to develop improved methods for computational genome annotation and to apply these methods to improve the annotation of genomic sequence data with a specific focus on human genome sequencing. The project resulted in a substantial body of published work. Notable contributions of this project were the identification of basecalling and lane tracking as error processes in genome sequencing and contributions to improved methods for these steps in genome sequencing. This technology improved the accuracy and throughput of genome sequence analysis. Probabilistic methods for physical map construction were developed. Improved methods for sequence alignment, alternative splicing analysis, promoter identification and NF kappa B response gene prediction were also developed.
- Research Organization:
- Washington University (US)
- Sponsoring Organization:
- USDOE Office of Environment, Safety and Health (EH); USDOE Office of Energy Research (ER) (US)
- DOE Contract Number:
- FG02-94ER61910
- OSTI ID:
- 826380
- Report Number(s):
- F006533; TRN: US200503%%211
- Resource Relation:
- Other Information: PBD: 1 Aug 1998
- Country of Publication:
- United States
- Language:
- English
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