skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Adaptive Response Against Spontaneous Neoplastic Transformation In Vitro Induced by Ionizing Radiation

Abstract

The goal of this project was to establish a dose response curve for radiation-induced neoplastic transformation of HeLa x skin fibroblast human hybrid cells in vitro under experimental conditions were an adaptive response, if it were induced, would have an opportunity to be expressed. During the first two years of the grant an exhaustive series of experiments were performed and the resulting data were reported at the 2000 Annual Meeting of the Radiation Research Society and then Subsequently published. The data showed that an adaptive response against spontaneous neoplastic transformation was seen up to doses of 10cGy of Cs-137 gamma rays. At dose of 30, 50 and 100 cGy the transformation frequencies were above background. This indicated that for this system, under the specific experimental conditions used, there was a threshold of somewhere between 10 and 30 cGy. The results also indicated some unexpected, though very interesting, correlations with relative risk estimates made from human epidemiologic studies.

Authors:
Publication Date:
Research Org.:
The Regents of The University of California (US)
Sponsoring Org.:
(US)
OSTI Identifier:
820345
Report Number(s):
DOE/ER/62876
TRN: US0305700
DOE Contract Number:  
FG07-99ER62876
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: 10 Nov 2003
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; FIBROBLASTS; IN VITRO; IONIZING RADIATIONS; TRANSFORMATIONS; RESPONSE FUNCTIONS; SKIN; CESIUM 137; RADIATION DOSES

Citation Formats

J. Leslie Redpath, Ph.D.. Adaptive Response Against Spontaneous Neoplastic Transformation In Vitro Induced by Ionizing Radiation. United States: N. p., 2003. Web. doi:10.2172/820345.
J. Leslie Redpath, Ph.D.. Adaptive Response Against Spontaneous Neoplastic Transformation In Vitro Induced by Ionizing Radiation. United States. doi:10.2172/820345.
J. Leslie Redpath, Ph.D.. Mon . "Adaptive Response Against Spontaneous Neoplastic Transformation In Vitro Induced by Ionizing Radiation". United States. doi:10.2172/820345. https://www.osti.gov/servlets/purl/820345.
@article{osti_820345,
title = {Adaptive Response Against Spontaneous Neoplastic Transformation In Vitro Induced by Ionizing Radiation},
author = {J. Leslie Redpath, Ph.D.},
abstractNote = {The goal of this project was to establish a dose response curve for radiation-induced neoplastic transformation of HeLa x skin fibroblast human hybrid cells in vitro under experimental conditions were an adaptive response, if it were induced, would have an opportunity to be expressed. During the first two years of the grant an exhaustive series of experiments were performed and the resulting data were reported at the 2000 Annual Meeting of the Radiation Research Society and then Subsequently published. The data showed that an adaptive response against spontaneous neoplastic transformation was seen up to doses of 10cGy of Cs-137 gamma rays. At dose of 30, 50 and 100 cGy the transformation frequencies were above background. This indicated that for this system, under the specific experimental conditions used, there was a threshold of somewhere between 10 and 30 cGy. The results also indicated some unexpected, though very interesting, correlations with relative risk estimates made from human epidemiologic studies.},
doi = {10.2172/820345},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Nov 10 00:00:00 EST 2003},
month = {Mon Nov 10 00:00:00 EST 2003}
}

Technical Report:

Save / Share: