Lesion detection and quantitation of positron emission mammography

Title: Lesion detection and quantitation of positron emission mammography

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Abstract

A Positron Emission Mammography (PEM) scanner dedicated to breast imaging is being developed at our laboratory. We have developed a list mode likelihood reconstruction algorithm for this scanner. Here we theoretically study the lesion detection and quantitation. The lesion detectability is studied theoretically using computer observers. We found that for the zero-order quadratic prior, the region of interest observer can achieve the performance of the prewhitening observer with a properly selected smoothing parameter. We also study the lesion quantitation using the test statistic of the region of interest observer. The theoretical expressions for the bias, variance, and ensemble mean squared error of the quantitation are derived. Computer simulations show that the theoretical predictions are in good agreement with the Monte Carlo results for both lesion detection and quantitation.

Authors:: Qi, Jinyi; Huesman, Ronald H

Publication Date:: 2001-12-01

Research Org.:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE Director, Office of Science, Office of Biological and Environmental Research, Medical Sciences Division; U.S. Department of Health and Human Services, Grant P01 HL25840, National Cancer Institute, Grant R01 CA 59794 (US)

OSTI Identifier:: 815475

Report Number(s):: LBNL-49397
R&D Project: 860530; TRN: US0304616

DOE Contract Number:: AC03-76SF00098

Resource Type:: Conference

Resource Relation:: Conference: IEEE Nuclear Science Symposium and Medical Imaging Conference, San Diego, CA (US), 11/10/2001; Other Information: PBD: 1 Dec 2001

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS; ALGORITHMS; COMPUTERIZED SIMULATION; COMPUTERS; DETECTION; MAMMARY GLANDS; PERFORMANCE; POSITRONS; STATISTICS; LESION DETECTION MAP RECONSTRUCTION EMISSION TOMOGRAPHY

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                    Qi, Jinyi, and Huesman, Ronald H. Lesion detection and quantitation of positron emission mammography.  United States: N. p., 2001. 
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                    Qi, Jinyi, & Huesman, Ronald H. Lesion detection and quantitation of positron emission mammography.  United States.

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                    Qi, Jinyi, and Huesman, Ronald H. Sat .  
        "Lesion detection and quantitation of positron emission mammography".  United States.  https://www.osti.gov/servlets/purl/815475.

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@article{osti_815475,

  title        = {Lesion detection and quantitation of positron emission mammography},

  author       = {Qi, Jinyi and Huesman, Ronald H},

  abstractNote = {A Positron Emission Mammography (PEM) scanner dedicated to breast imaging is being developed at our laboratory. We have developed a list mode likelihood reconstruction algorithm for this scanner. Here we theoretically study the lesion detection and quantitation. The lesion detectability is studied theoretically using computer observers. We found that for the zero-order quadratic prior, the region of interest observer can achieve the performance of the prewhitening observer with a properly selected smoothing parameter. We also study the lesion quantitation using the test statistic of the region of interest observer. The theoretical expressions for the bias, variance, and ensemble mean squared error of the quantitation are derived. Computer simulations show that the theoretical predictions are in good agreement with the Monte Carlo results for both lesion detection and quantitation.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/815475},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2001},

  month        = {12}

}

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