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Title: Initial sequencing and comparative analysis of the mouse genome

Abstract

The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.

Authors:
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Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Director, Office of Science, Office of Biological and Environmental Research (US)
OSTI Identifier:
815380
Report Number(s):
LBNL-52923
R&D Project: LGFGAA; TRN: US200319%%192
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Journal Article
Journal Name:
Nature
Additional Journal Information:
Journal Volume: 420; Other Information: Journal Publication Date: December 5, 2002; PBD: 15 Dec 2002
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; GENES; IMMUNITY; PROTEINS; REPRODUCTION

Citation Formats

Waterston, Robert H., Lindblad-Toh, Kerstin, Birney, Ewan, Rogers, Jane, Abril, Josep F., Agarwal, Pankaj, Agarwala, Richa, Ainscough, Rachel, Alexandersson, Marina, An, Peter, Antonarakis, Stylianos E., Attwood, John, Baertsch, Robert, Bailey, Jonathon, Barlow, Karen, Beck, Stephan, Berry, Eric, Birren, Bruce, Bloom, Toby, Bork, Peer, Botcherby, Marc, Bray, Nicolas, Brent, Michael R., Brown, Daniel G., Brown, Stephen D., Bult, Carol, Burton, John, Butler, Jonathan, Campbell, Robert D., Carninci, Piero, Cawley, Simon, Chiaromonte, Francesca, Chinwalla, Asif T., Church, Deanna M., Clamp, Michele, Clee, Christopher, Collins, Francis S., Cook, Lisa L., Copley, Richard R., Coulson, Alan, Couronne, Olivier, Cuff, James, Curwen, Val, Cutts, Tim, Daly, Mark, David, Robert, Davies, Joy, Delehaunty, Kimberly D., Deri, Justin, Dermitzakis, Emmanouil T., Dewey, Colin, Dickens, Nicholas J., Diekhans, Mark, Dodge, Sheila, Dubchak, Inna, Dunn, Diane M., Eddy, Sean R., Elnitski, Laura, Emes, Richard D., Eswara, Pallavi, Eyras, Eduardo, Felsenfeld, Adam, Fewell, Ginger A., Flicek, Paul, Foley, Karen, Frankel, Wayne N., Fulton, Lucinda A., Fulton, Robert S., Furey, Terrence S., Gage, Diane, Gibbs, Richard A., Glusman, Gustavo, Gnerre, Sante, Goldman, Nick, Goodstadt, Leo, Grafham, Darren, Graves, Tina A., Green, Eric D., Gregory, Simon, Guigo, Roderic, Guyer, Mark, Hardison, Ross C., Haussler, David, Hayashizaki, Yoshihide, Hillier, LaDeana W., Hinrichs, Angela, Hlavina, Wratko, Holzer, Timothy, Hsu, Fan, Hua, Axin, Hubbard, Tim, Hunt, Adrienne, Jackson, Ian, Jaffe, David B., Johnson, L. Steven, Jones, Matthew, Jones, Thomas A., Joy, Ann, Kamal, Michael, Karlsson, Elinor K., Karolchik, Donna, Kasprzyk, Arkadiusz, Kawai, Jun, Keibler, Evan, Kells, Cristyn, Kent, W. James, Kirby, Andrew, Kolbe, Diana L., Korf, Ian, Kucherlapati, Raju S., Kulbokas III, Edward J., Kulp, David, Landers, Tom, Leger, J.P., Leonard, Steven, Letunic, Ivica, Levine, Rosie, and et al. Initial sequencing and comparative analysis of the mouse genome. United States: N. p., 2002. Web.
Waterston, Robert H., Lindblad-Toh, Kerstin, Birney, Ewan, Rogers, Jane, Abril, Josep F., Agarwal, Pankaj, Agarwala, Richa, Ainscough, Rachel, Alexandersson, Marina, An, Peter, Antonarakis, Stylianos E., Attwood, John, Baertsch, Robert, Bailey, Jonathon, Barlow, Karen, Beck, Stephan, Berry, Eric, Birren, Bruce, Bloom, Toby, Bork, Peer, Botcherby, Marc, Bray, Nicolas, Brent, Michael R., Brown, Daniel G., Brown, Stephen D., Bult, Carol, Burton, John, Butler, Jonathan, Campbell, Robert D., Carninci, Piero, Cawley, Simon, Chiaromonte, Francesca, Chinwalla, Asif T., Church, Deanna M., Clamp, Michele, Clee, Christopher, Collins, Francis S., Cook, Lisa L., Copley, Richard R., Coulson, Alan, Couronne, Olivier, Cuff, James, Curwen, Val, Cutts, Tim, Daly, Mark, David, Robert, Davies, Joy, Delehaunty, Kimberly D., Deri, Justin, Dermitzakis, Emmanouil T., Dewey, Colin, Dickens, Nicholas J., Diekhans, Mark, Dodge, Sheila, Dubchak, Inna, Dunn, Diane M., Eddy, Sean R., Elnitski, Laura, Emes, Richard D., Eswara, Pallavi, Eyras, Eduardo, Felsenfeld, Adam, Fewell, Ginger A., Flicek, Paul, Foley, Karen, Frankel, Wayne N., Fulton, Lucinda A., Fulton, Robert S., Furey, Terrence S., Gage, Diane, Gibbs, Richard A., Glusman, Gustavo, Gnerre, Sante, Goldman, Nick, Goodstadt, Leo, Grafham, Darren, Graves, Tina A., Green, Eric D., Gregory, Simon, Guigo, Roderic, Guyer, Mark, Hardison, Ross C., Haussler, David, Hayashizaki, Yoshihide, Hillier, LaDeana W., Hinrichs, Angela, Hlavina, Wratko, Holzer, Timothy, Hsu, Fan, Hua, Axin, Hubbard, Tim, Hunt, Adrienne, Jackson, Ian, Jaffe, David B., Johnson, L. Steven, Jones, Matthew, Jones, Thomas A., Joy, Ann, Kamal, Michael, Karlsson, Elinor K., Karolchik, Donna, Kasprzyk, Arkadiusz, Kawai, Jun, Keibler, Evan, Kells, Cristyn, Kent, W. James, Kirby, Andrew, Kolbe, Diana L., Korf, Ian, Kucherlapati, Raju S., Kulbokas III, Edward J., Kulp, David, Landers, Tom, Leger, J.P., Leonard, Steven, Letunic, Ivica, Levine, Rosie, & et al. Initial sequencing and comparative analysis of the mouse genome. United States.
Waterston, Robert H., Lindblad-Toh, Kerstin, Birney, Ewan, Rogers, Jane, Abril, Josep F., Agarwal, Pankaj, Agarwala, Richa, Ainscough, Rachel, Alexandersson, Marina, An, Peter, Antonarakis, Stylianos E., Attwood, John, Baertsch, Robert, Bailey, Jonathon, Barlow, Karen, Beck, Stephan, Berry, Eric, Birren, Bruce, Bloom, Toby, Bork, Peer, Botcherby, Marc, Bray, Nicolas, Brent, Michael R., Brown, Daniel G., Brown, Stephen D., Bult, Carol, Burton, John, Butler, Jonathan, Campbell, Robert D., Carninci, Piero, Cawley, Simon, Chiaromonte, Francesca, Chinwalla, Asif T., Church, Deanna M., Clamp, Michele, Clee, Christopher, Collins, Francis S., Cook, Lisa L., Copley, Richard R., Coulson, Alan, Couronne, Olivier, Cuff, James, Curwen, Val, Cutts, Tim, Daly, Mark, David, Robert, Davies, Joy, Delehaunty, Kimberly D., Deri, Justin, Dermitzakis, Emmanouil T., Dewey, Colin, Dickens, Nicholas J., Diekhans, Mark, Dodge, Sheila, Dubchak, Inna, Dunn, Diane M., Eddy, Sean R., Elnitski, Laura, Emes, Richard D., Eswara, Pallavi, Eyras, Eduardo, Felsenfeld, Adam, Fewell, Ginger A., Flicek, Paul, Foley, Karen, Frankel, Wayne N., Fulton, Lucinda A., Fulton, Robert S., Furey, Terrence S., Gage, Diane, Gibbs, Richard A., Glusman, Gustavo, Gnerre, Sante, Goldman, Nick, Goodstadt, Leo, Grafham, Darren, Graves, Tina A., Green, Eric D., Gregory, Simon, Guigo, Roderic, Guyer, Mark, Hardison, Ross C., Haussler, David, Hayashizaki, Yoshihide, Hillier, LaDeana W., Hinrichs, Angela, Hlavina, Wratko, Holzer, Timothy, Hsu, Fan, Hua, Axin, Hubbard, Tim, Hunt, Adrienne, Jackson, Ian, Jaffe, David B., Johnson, L. Steven, Jones, Matthew, Jones, Thomas A., Joy, Ann, Kamal, Michael, Karlsson, Elinor K., Karolchik, Donna, Kasprzyk, Arkadiusz, Kawai, Jun, Keibler, Evan, Kells, Cristyn, Kent, W. James, Kirby, Andrew, Kolbe, Diana L., Korf, Ian, Kucherlapati, Raju S., Kulbokas III, Edward J., Kulp, David, Landers, Tom, Leger, J.P., Leonard, Steven, Letunic, Ivica, Levine, Rosie, and et al. Sun . "Initial sequencing and comparative analysis of the mouse genome". United States.
@article{osti_815380,
title = {Initial sequencing and comparative analysis of the mouse genome},
author = {Waterston, Robert H. and Lindblad-Toh, Kerstin and Birney, Ewan and Rogers, Jane and Abril, Josep F. and Agarwal, Pankaj and Agarwala, Richa and Ainscough, Rachel and Alexandersson, Marina and An, Peter and Antonarakis, Stylianos E. and Attwood, John and Baertsch, Robert and Bailey, Jonathon and Barlow, Karen and Beck, Stephan and Berry, Eric and Birren, Bruce and Bloom, Toby and Bork, Peer and Botcherby, Marc and Bray, Nicolas and Brent, Michael R. and Brown, Daniel G. and Brown, Stephen D. and Bult, Carol and Burton, John and Butler, Jonathan and Campbell, Robert D. and Carninci, Piero and Cawley, Simon and Chiaromonte, Francesca and Chinwalla, Asif T. and Church, Deanna M. and Clamp, Michele and Clee, Christopher and Collins, Francis S. and Cook, Lisa L. and Copley, Richard R. and Coulson, Alan and Couronne, Olivier and Cuff, James and Curwen, Val and Cutts, Tim and Daly, Mark and David, Robert and Davies, Joy and Delehaunty, Kimberly D. and Deri, Justin and Dermitzakis, Emmanouil T. and Dewey, Colin and Dickens, Nicholas J. and Diekhans, Mark and Dodge, Sheila and Dubchak, Inna and Dunn, Diane M. and Eddy, Sean R. and Elnitski, Laura and Emes, Richard D. and Eswara, Pallavi and Eyras, Eduardo and Felsenfeld, Adam and Fewell, Ginger A. and Flicek, Paul and Foley, Karen and Frankel, Wayne N. and Fulton, Lucinda A. and Fulton, Robert S. and Furey, Terrence S. and Gage, Diane and Gibbs, Richard A. and Glusman, Gustavo and Gnerre, Sante and Goldman, Nick and Goodstadt, Leo and Grafham, Darren and Graves, Tina A. and Green, Eric D. and Gregory, Simon and Guigo, Roderic and Guyer, Mark and Hardison, Ross C. and Haussler, David and Hayashizaki, Yoshihide and Hillier, LaDeana W. and Hinrichs, Angela and Hlavina, Wratko and Holzer, Timothy and Hsu, Fan and Hua, Axin and Hubbard, Tim and Hunt, Adrienne and Jackson, Ian and Jaffe, David B. and Johnson, L. Steven and Jones, Matthew and Jones, Thomas A. and Joy, Ann and Kamal, Michael and Karlsson, Elinor K. and Karolchik, Donna and Kasprzyk, Arkadiusz and Kawai, Jun and Keibler, Evan and Kells, Cristyn and Kent, W. James and Kirby, Andrew and Kolbe, Diana L. and Korf, Ian and Kucherlapati, Raju S. and Kulbokas III, Edward J. and Kulp, David and Landers, Tom and Leger, J.P. and Leonard, Steven and Letunic, Ivica and Levine, Rosie and et al.},
abstractNote = {The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.},
doi = {},
journal = {Nature},
number = ,
volume = 420,
place = {United States},
year = {2002},
month = {12}
}