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Title: A D-D/D-T fusion reaction based neutron generator system for liver tumor BNCT

Abstract

Boron-neutron capture therapy (BNCT) is an experimental radiation treatment modality used for highly malignant tumor treatments. Prior to irradiation with low energetic neutrons, a 10B compound is located selectively in the tumor cells. The effect of the treatment is based on the high LET radiation released in the {sup 10}B(n,{alpha}){sup 7}Li reaction with thermal neutrons. BNCT has been used experimentally for brain tumor and melanoma treatments. Lately applications of other severe tumor type treatments have been introduced. Results have shown that liver tumors can also be treated by BNCT. At Lawrence Berkeley National Laboratory, various compact neutron generators based on D-D or D-T fusion reactions are being developed. The earlier theoretical studies of the D-D or D-T fusion reaction based neutron generators have shown that the optimal moderator and reflector configuration for brain tumor BNCT can be created. In this work, the applicability of 2.5 MeV neutrons for liver tumor BNCT application was studied. The optimal neutron energy for external liver treatments is not known. Neutron beams of different energies (1eV < E < 100 keV) were simulated and the dose distribution in the liver was calculated with the MCNP simulation code. In order to obtain the optimal neutron energymore » spectrum with the D-D neutrons, various moderator designs were performed using MCNP simulations. In this article the neutron spectrum and the optimized beam shaping assembly for liver tumor treatments is presented.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
Office of Science. Fusion Energy Sciences (US)
OSTI Identifier:
810876
Report Number(s):
LBNL-52430
R&D Project: Z2IS04; TRN: US0302829
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Conference
Resource Relation:
Conference: Accelerator Applications in a Nuclear Rennasissance (AccApp03), San Diego, CA (US), 06/01/2003--06/05/2003; Other Information: PBD: 2 Apr 2003
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS; 70 PLASMA PHYSICS AND FUSION TECHNOLOGY; ACCELERATORS; BEAM SHAPING; IRRADIATION; LIVER; NEOPLASMS; NEUTRON BEAMS; NEUTRON GENERATORS; NEUTRONS; RADIATION DOSE DISTRIBUTIONS; RADIATIONS; THERMAL NEUTRONS; TUMOR CELLS

Citation Formats

Koivunoro, H, Lou, T P, Leung, K N, and Reijonen, J. A D-D/D-T fusion reaction based neutron generator system for liver tumor BNCT. United States: N. p., 2003. Web.
Koivunoro, H, Lou, T P, Leung, K N, & Reijonen, J. A D-D/D-T fusion reaction based neutron generator system for liver tumor BNCT. United States.
Koivunoro, H, Lou, T P, Leung, K N, and Reijonen, J. Wed . "A D-D/D-T fusion reaction based neutron generator system for liver tumor BNCT". United States. https://www.osti.gov/servlets/purl/810876.
@article{osti_810876,
title = {A D-D/D-T fusion reaction based neutron generator system for liver tumor BNCT},
author = {Koivunoro, H and Lou, T P and Leung, K N and Reijonen, J},
abstractNote = {Boron-neutron capture therapy (BNCT) is an experimental radiation treatment modality used for highly malignant tumor treatments. Prior to irradiation with low energetic neutrons, a 10B compound is located selectively in the tumor cells. The effect of the treatment is based on the high LET radiation released in the {sup 10}B(n,{alpha}){sup 7}Li reaction with thermal neutrons. BNCT has been used experimentally for brain tumor and melanoma treatments. Lately applications of other severe tumor type treatments have been introduced. Results have shown that liver tumors can also be treated by BNCT. At Lawrence Berkeley National Laboratory, various compact neutron generators based on D-D or D-T fusion reactions are being developed. The earlier theoretical studies of the D-D or D-T fusion reaction based neutron generators have shown that the optimal moderator and reflector configuration for brain tumor BNCT can be created. In this work, the applicability of 2.5 MeV neutrons for liver tumor BNCT application was studied. The optimal neutron energy for external liver treatments is not known. Neutron beams of different energies (1eV < E < 100 keV) were simulated and the dose distribution in the liver was calculated with the MCNP simulation code. In order to obtain the optimal neutron energy spectrum with the D-D neutrons, various moderator designs were performed using MCNP simulations. In this article the neutron spectrum and the optimized beam shaping assembly for liver tumor treatments is presented.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {4}
}

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