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Title: Positron Emission Mammography with Multiple Angle Acquisition

Abstract

Positron emission mammography (PEM) of F-18 fluorodeoxyglucose (FbG) uptake in breast tumors with dedicated detectors typically has been accomplished with two planar detectors in a fixed position with the breast under compression. The potential use of PEM imaging at two detector positions to guide stereotactic breast biopsy has motivated us to use PEM coincidence data acquired at two or more detector positions together in a single image reconstruction. Multiple angle PEM acquisition and iterative image reconstruction were investigated using point source and compressed breast phantom acquisitions with 5, 9, 12 and 15 mm diameter spheres and a simulated tumor:background activity concentration ratio of 6:1. Image reconstruction was performed with an iterative MLEM algorithm that used coincidence events between any two detector pixels on opposed detector heads at each detector position. This present study compared two acquisition protocols: 2 angle acquisition with detector angular positions of -15 and +15 degrees and 11 angle acquisition with detector positions spaced at 3 degree increments over the range -15 to +15 degrees. Three-dimensional image resolution was assessed for the point source acquisitions, and contrast and signal-to-noise metrics were evaluated for the compressed breast phantom with different simulated tumor sizes. Radial and tangential resolutions weremore » similar for the two protocols, while normal resolution was better for the 2 angle acquisition. Analysis is complicated by the asymmetric point spread functions. Signal- to-noise vs. contrast tradeoffs were better for 11 angle acquisition for the smallest visible 9 mm sphere, while tradeoff results were mixed for the larger and more easily visible 12 mm and 15 mm diameter spheres. Additional study is needed to better understand the performance of limited angle tomography for PEM. PEM tomography experiments with complete angular sampling are planned.« less

Authors:
; ;
Publication Date:
Research Org.:
Thomas Jefferson National Accelerator Facility, Newport News, VA (US)
Sponsoring Org.:
USDOE Office of Energy Research (ER) (US)
OSTI Identifier:
805771
Report Number(s):
JLAB-PHY-02-67; DOE/ER/40150-2406
TRN: US0300945
DOE Contract Number:  
AC05-84ER40150
Resource Type:
Conference
Resource Relation:
Conference: 2002 IEEE Nuclear Science Symposium and Medical Imaging Conference, Norfolk, VA (US), 11/2002; Other Information: PBD: 1 Nov 2002
Country of Publication:
United States
Language:
English
Subject:
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS; ALGORITHMS; BIOPSY; COMPRESSION; CONCENTRATION RATIO; FLUORODEOXYGLUCOSE; MAMMARY GLANDS; METRICS; NEOPLASMS; PHANTOMS; POINT SOURCES; POSITRONS; RESOLUTION; SAMPLING; TOMOGRAPHY

Citation Formats

Smith, Mark F, Majewski, Stan, and Raylman, Raymond R. Positron Emission Mammography with Multiple Angle Acquisition. United States: N. p., 2002. Web.
Smith, Mark F, Majewski, Stan, & Raylman, Raymond R. Positron Emission Mammography with Multiple Angle Acquisition. United States.
Smith, Mark F, Majewski, Stan, and Raylman, Raymond R. Fri . "Positron Emission Mammography with Multiple Angle Acquisition". United States. https://www.osti.gov/servlets/purl/805771.
@article{osti_805771,
title = {Positron Emission Mammography with Multiple Angle Acquisition},
author = {Smith, Mark F and Majewski, Stan and Raylman, Raymond R},
abstractNote = {Positron emission mammography (PEM) of F-18 fluorodeoxyglucose (FbG) uptake in breast tumors with dedicated detectors typically has been accomplished with two planar detectors in a fixed position with the breast under compression. The potential use of PEM imaging at two detector positions to guide stereotactic breast biopsy has motivated us to use PEM coincidence data acquired at two or more detector positions together in a single image reconstruction. Multiple angle PEM acquisition and iterative image reconstruction were investigated using point source and compressed breast phantom acquisitions with 5, 9, 12 and 15 mm diameter spheres and a simulated tumor:background activity concentration ratio of 6:1. Image reconstruction was performed with an iterative MLEM algorithm that used coincidence events between any two detector pixels on opposed detector heads at each detector position. This present study compared two acquisition protocols: 2 angle acquisition with detector angular positions of -15 and +15 degrees and 11 angle acquisition with detector positions spaced at 3 degree increments over the range -15 to +15 degrees. Three-dimensional image resolution was assessed for the point source acquisitions, and contrast and signal-to-noise metrics were evaluated for the compressed breast phantom with different simulated tumor sizes. Radial and tangential resolutions were similar for the two protocols, while normal resolution was better for the 2 angle acquisition. Analysis is complicated by the asymmetric point spread functions. Signal- to-noise vs. contrast tradeoffs were better for 11 angle acquisition for the smallest visible 9 mm sphere, while tradeoff results were mixed for the larger and more easily visible 12 mm and 15 mm diameter spheres. Additional study is needed to better understand the performance of limited angle tomography for PEM. PEM tomography experiments with complete angular sampling are planned.},
doi = {},
url = {https://www.osti.gov/biblio/805771}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {11}
}

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