Oxime-induced reactivation of acetylcholinesterase inhibited by organophosphinates. (Reannouncement with new availability information)
Technical Report
·
OSTI ID:80534
The comparative potency of oximes for reactivation of inhibited eel acetylcholinesterase (AChE) in vitro is dependent on the organophosphinate inhibitor. Some of the data, dealing with a reference organophosphonate, support the conclusion of other investigators that the oxime potency order is also dependent on the inhibiting phosphonate. This work was done to identify more clearly the nature of phosphinylated AChE with regard to oxime reactivation potency and the potential of phosphinates as pretreatment drugs to protect AChE against organophosphonate poisoning.
- Research Organization:
- Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD (United States)
- OSTI ID:
- 80534
- Report Number(s):
- AD-A-232968/8/XAB; USAMRICD-P-88-022; TRN: 51990371
- Resource Relation:
- Other Information: PBD: 1990
- Country of Publication:
- United States
- Language:
- English
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