skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Maximizing the Efficacy of Accelerator-Produced Neutrons for BNCT

Abstract

Production of neutrons for boron neutron capture therapy (BNCT) treatment of malignant brain tumors will best be served if the neutrons can be produced by accelerators rather than nuclear reactors. The neutron production reaction that has been most thoroughly examined using accelerators is {sup 7}Li(n, p){sup 7}Be, generally on a thick lithium target. The threshold for this reactor is 1.88 MeV, and the yield curve for neutron production rises quite rapidly up to 2.3 MeV, where the positive slope is reduced significantly. In considering the design of a neutron production device, it has been traditional to use proton energies in the 2.4- to 2.5-MeV range. Over the last several years, our group has been working with lower-energy protons, just above the threshold for neutron production. The advantage is that the neutrons produced would have much lower energy and hence need much less moderator. The principal disadvantage of operating at these near-threshold energies is that the yield from the target is substantially reduced from that at or near 2.5-MeV proton energy. Table I shows the results of calculations to find an optimum energy for 3-mA proton beam on target. In general, we have concluded that 1.96 to 1.98 MeV is probablymore » optimum for a tumor 5 cm below the skull.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Idaho State University, Pocatello, ID (US); M. D. Anderson Medical Center, Houston, TX (US)
Sponsoring Org.:
none (US)
OSTI Identifier:
786192
Report Number(s):
ISSN 0003-018X; CODEN TANSAO
ISSN 0003-018X; CODEN TANSAO; TRN: US0109306
Resource Type:
Conference
Resource Relation:
Conference: 2000 Annual Meeting, San Diego, CA (US), 06/04/2000--06/08/2000; Other Information: Transactions of the American Nuclear Society, Volume 82; PBD: 4 Jun 2000
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 43 PARTICLE ACCELERATORS; ACCELERATORS; BORON; NEOPLASMS; NEUTRON CAPTURE THERAPY; PROTON BEAMS; MEV RANGE 01-10; NEUTRON GENERATORS; DESIGN; OPTIMIZATION

Citation Formats

Jay F. Kunze, J. Frank Harmon, Rajat Kudchadker, and Chad L. Lee. Maximizing the Efficacy of Accelerator-Produced Neutrons for BNCT. United States: N. p., 2000. Web.
Jay F. Kunze, J. Frank Harmon, Rajat Kudchadker, & Chad L. Lee. Maximizing the Efficacy of Accelerator-Produced Neutrons for BNCT. United States.
Jay F. Kunze, J. Frank Harmon, Rajat Kudchadker, and Chad L. Lee. Sun . "Maximizing the Efficacy of Accelerator-Produced Neutrons for BNCT". United States.
@article{osti_786192,
title = {Maximizing the Efficacy of Accelerator-Produced Neutrons for BNCT},
author = {Jay F. Kunze and J. Frank Harmon and Rajat Kudchadker and Chad L. Lee},
abstractNote = {Production of neutrons for boron neutron capture therapy (BNCT) treatment of malignant brain tumors will best be served if the neutrons can be produced by accelerators rather than nuclear reactors. The neutron production reaction that has been most thoroughly examined using accelerators is {sup 7}Li(n, p){sup 7}Be, generally on a thick lithium target. The threshold for this reactor is 1.88 MeV, and the yield curve for neutron production rises quite rapidly up to 2.3 MeV, where the positive slope is reduced significantly. In considering the design of a neutron production device, it has been traditional to use proton energies in the 2.4- to 2.5-MeV range. Over the last several years, our group has been working with lower-energy protons, just above the threshold for neutron production. The advantage is that the neutrons produced would have much lower energy and hence need much less moderator. The principal disadvantage of operating at these near-threshold energies is that the yield from the target is substantially reduced from that at or near 2.5-MeV proton energy. Table I shows the results of calculations to find an optimum energy for 3-mA proton beam on target. In general, we have concluded that 1.96 to 1.98 MeV is probably optimum for a tumor 5 cm below the skull.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {6}
}

Conference:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this conference proceeding.

Save / Share: