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Title: GENETIC AND MOLECULAR ANALYSIS OF DNA DAMAGE REPAIR AND TOLERANCE PATHWAYS.

Abstract

Radiation can damage cellular components, including DNA. Organisms have developed a panoply of means of dealing with DNA damage. Some repair paths have rather narrow substrate specificity (e.g. photolyases), which act on specific pyrimidine photoproducts in a specific type (e.g., DNA) and conformation (double-stranded B conformation) of nucleic acid. Others, for example, nucleotide excision repair, deal with larger classes of damages, in this case bulky adducts in DNA. A detailed discussion of DNA repair mechanisms is beyond the scope of this article, but one can be found in the excellent book of Friedberg et al. [1] for further detail. However, some DNA damages and paths for repair of those damages important for photobiology will be outlined below as a basis for the specific examples of genetic and molecular analysis that will be presented below.

Authors:
Publication Date:
Research Org.:
Brookhaven National Lab., Upton, NY (US)
Sponsoring Org.:
USDOE Office of Energy Research (ER) (US)
OSTI Identifier:
785050
Report Number(s):
BNL-68537; KP1102020
R&D Project: BO086; KP1102020; TRN: AH200131%%107
DOE Contract Number:
AC02-98CH10886
Resource Type:
Book
Resource Relation:
Other Information: BOOK TITLE: ENVIRONMENTAL RADIATION: IMPACT ON ECOSYSTEMS..., GHETTI,F.; PBD: 26 Jul 2001
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DNA; DNA DAMAGES; DNA REPAIR; EXCISION REPAIR; GENETICS; NUCLEIC ACIDS; REPAIR; TOLERANCE

Citation Formats

SUTHERLAND, B.M. GENETIC AND MOLECULAR ANALYSIS OF DNA DAMAGE REPAIR AND TOLERANCE PATHWAYS.. United States: N. p., 2001. Web.
SUTHERLAND, B.M. GENETIC AND MOLECULAR ANALYSIS OF DNA DAMAGE REPAIR AND TOLERANCE PATHWAYS.. United States.
SUTHERLAND, B.M. 2001. "GENETIC AND MOLECULAR ANALYSIS OF DNA DAMAGE REPAIR AND TOLERANCE PATHWAYS.". United States. doi:. https://www.osti.gov/servlets/purl/785050.
@article{osti_785050,
title = {GENETIC AND MOLECULAR ANALYSIS OF DNA DAMAGE REPAIR AND TOLERANCE PATHWAYS.},
author = {SUTHERLAND, B.M.},
abstractNote = {Radiation can damage cellular components, including DNA. Organisms have developed a panoply of means of dealing with DNA damage. Some repair paths have rather narrow substrate specificity (e.g. photolyases), which act on specific pyrimidine photoproducts in a specific type (e.g., DNA) and conformation (double-stranded B conformation) of nucleic acid. Others, for example, nucleotide excision repair, deal with larger classes of damages, in this case bulky adducts in DNA. A detailed discussion of DNA repair mechanisms is beyond the scope of this article, but one can be found in the excellent book of Friedberg et al. [1] for further detail. However, some DNA damages and paths for repair of those damages important for photobiology will be outlined below as a basis for the specific examples of genetic and molecular analysis that will be presented below.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = 2001,
month = 7
}

Book:
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