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Title: Production and application of synthetic precursors labeled with carbon-11 and fluorine-18

Abstract

It is evident from this chapter that there is enormous flexibility both in the selection of the nature of the radioisotope and ways to generate it, as well as in the selection of the labeling precursor to appropriately attach that radioisotope to some larger biomolecule of interest. The arsenal of radiolabeling precursors now available to the chemist is quite extensive, and without a doubt will continue to grow as chemists develop new ones. However, the upcoming years will perhaps reflect a greater effort in refining existing methods for preparing some of those precursors that are already available to us. For example, the use of solid-phase reactions to accomplish in a single step what would normally take several using conventional solvent-based reactions has already been shown to work in many occasions. The obvious advantage here is that processes become more amenable to system automation thus affording greater reliability in day-to-day operations. There are perhaps other technologies in science that have yet to be realized by the chemist in the PET laboratory that could provide a similar or even a greater benefit. One only needs to be open to new ideas, and imaginative enough to apply them to the problems at hand.

Authors:
Publication Date:
Research Org.:
Brookhaven National Lab., Upton, NY (US)
Sponsoring Org.:
USDOE Office of Energy Research (ER) (US)
OSTI Identifier:
781827
Report Number(s):
BNL-68184; KP140102
R&D Project: CO11; KP140102; TRN: US0102966
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Book
Resource Relation:
Other Information: PBD: 2 Apr 2001
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; CARBON 11; FLUORINE 18; PRECURSOR; LABELLED COMPOUNDS; PRODUCTION; RADIOISOTOPES; RADIOPHARMACEUTICALS

Citation Formats

Ferrieri, R A. Production and application of synthetic precursors labeled with carbon-11 and fluorine-18. United States: N. p., 2001. Web.
Ferrieri, R A. Production and application of synthetic precursors labeled with carbon-11 and fluorine-18. United States.
Ferrieri, R A. Mon . "Production and application of synthetic precursors labeled with carbon-11 and fluorine-18". United States. https://www.osti.gov/servlets/purl/781827.
@article{osti_781827,
title = {Production and application of synthetic precursors labeled with carbon-11 and fluorine-18},
author = {Ferrieri, R A},
abstractNote = {It is evident from this chapter that there is enormous flexibility both in the selection of the nature of the radioisotope and ways to generate it, as well as in the selection of the labeling precursor to appropriately attach that radioisotope to some larger biomolecule of interest. The arsenal of radiolabeling precursors now available to the chemist is quite extensive, and without a doubt will continue to grow as chemists develop new ones. However, the upcoming years will perhaps reflect a greater effort in refining existing methods for preparing some of those precursors that are already available to us. For example, the use of solid-phase reactions to accomplish in a single step what would normally take several using conventional solvent-based reactions has already been shown to work in many occasions. The obvious advantage here is that processes become more amenable to system automation thus affording greater reliability in day-to-day operations. There are perhaps other technologies in science that have yet to be realized by the chemist in the PET laboratory that could provide a similar or even a greater benefit. One only needs to be open to new ideas, and imaginative enough to apply them to the problems at hand.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {4}
}

Book:
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