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Title: Synthesis of high specific activity [ethyl-1,2-3H]-labeled chlorpyrifos oxon and diazoxon

Abstract

[Ethyl-1,2-3H] Chlorpyrifos oxon and [ethyl-1,2-3H] diazoxon were synthesized at a specific activity of 79 and 58 Ci/mmol, respectively, by catalytic tritiation of the corresponding monovinyl analogs over Pd/C. Direct evidence is provided that the high specific activity results from isotope exchange of the terminal vinylic protons prior to saturation of the double bond. This radiosynthesis procedure is applicable to the toxicologically-important oxon metabolites of many commercial O-O-diethyl phosphorothioate pesticides.

Authors:
; ; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab., CA (US)
Sponsoring Org.:
National Institutes of Health (US)
OSTI Identifier:
779735
Report Number(s):
LBNL-45857
Journal ID: ISSN 0362-4803; JLCRD4; R&D Project: 865036; TRN: US0102269
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Journal Article
Journal Name:
Journal of Labelled Compounds and Radiopharmaceuticals
Additional Journal Information:
Journal Volume: 43; Journal Issue: 13; Other Information: Journal Publication Date: Nov. 2000; PBD: 1 May 2000; Journal ID: ISSN 0362-4803
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; DIAZO COMPOUNDS; ORGANIC CHLORINE COMPOUNDS; CHEMICAL PREPARATION; LABELLED COMPOUNDS; ISOTOPIC EXCHANGE; METABOLITES; PESTICIDES; TRITIUM; ACETYLCHOLINESTERASE CHLORPYRIFOS OXON DIAZOXON INSECTICIDE TRITIUM ISOTOPE EXCHANGE

Citation Formats

Zhang, Nanjing, Morimoto, Hiromi, Williams, Philip G., and Casida, John E. Synthesis of high specific activity [ethyl-1,2-3H]-labeled chlorpyrifos oxon and diazoxon. United States: N. p., 2000. Web. doi:10.1002/1099-1344(200011)43:13<1275::AID-JLCR416>3.3.CO;2-7.
Zhang, Nanjing, Morimoto, Hiromi, Williams, Philip G., & Casida, John E. Synthesis of high specific activity [ethyl-1,2-3H]-labeled chlorpyrifos oxon and diazoxon. United States. doi:10.1002/1099-1344(200011)43:13<1275::AID-JLCR416>3.3.CO;2-7.
Zhang, Nanjing, Morimoto, Hiromi, Williams, Philip G., and Casida, John E. Mon . "Synthesis of high specific activity [ethyl-1,2-3H]-labeled chlorpyrifos oxon and diazoxon". United States. doi:10.1002/1099-1344(200011)43:13<1275::AID-JLCR416>3.3.CO;2-7.
@article{osti_779735,
title = {Synthesis of high specific activity [ethyl-1,2-3H]-labeled chlorpyrifos oxon and diazoxon},
author = {Zhang, Nanjing and Morimoto, Hiromi and Williams, Philip G. and Casida, John E},
abstractNote = {[Ethyl-1,2-3H] Chlorpyrifos oxon and [ethyl-1,2-3H] diazoxon were synthesized at a specific activity of 79 and 58 Ci/mmol, respectively, by catalytic tritiation of the corresponding monovinyl analogs over Pd/C. Direct evidence is provided that the high specific activity results from isotope exchange of the terminal vinylic protons prior to saturation of the double bond. This radiosynthesis procedure is applicable to the toxicologically-important oxon metabolites of many commercial O-O-diethyl phosphorothioate pesticides.},
doi = {10.1002/1099-1344(200011)43:13<1275::AID-JLCR416>3.3.CO;2-7},
journal = {Journal of Labelled Compounds and Radiopharmaceuticals},
issn = {0362-4803},
number = 13,
volume = 43,
place = {United States},
year = {2000},
month = {5}
}