skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Active conservation of noncoding sequences revealed by three-way species comparisons

Abstract

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab., CA (US)
Sponsoring Org.:
USDOE Director, Office of Science. Office of Biological and Environmental Research. Life Sciences Division; National Institutes of Health (US)
OSTI Identifier:
771850
Report Number(s):
LBNL-45762
R&D Project: 871613; TRN: AH200104%%344
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Journal Article
Journal Name:
Genome Research
Additional Journal Information:
Journal Volume: 10; Journal Issue: 9; Other Information: PBD: 1 May 2000
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DNA; FUNCTIONALS; GENES; NONCODING SEQUENCES COMPARISONS

Citation Formats

Dubchak, I., Mayor, C., Brudno, M., Pachter, L., Rubin, E.M., and Frazer, K.A. Active conservation of noncoding sequences revealed by three-way species comparisons. United States: N. p., 2000. Web. doi:10.1101/gr.142200.
Dubchak, I., Mayor, C., Brudno, M., Pachter, L., Rubin, E.M., & Frazer, K.A. Active conservation of noncoding sequences revealed by three-way species comparisons. United States. doi:10.1101/gr.142200.
Dubchak, I., Mayor, C., Brudno, M., Pachter, L., Rubin, E.M., and Frazer, K.A. Mon . "Active conservation of noncoding sequences revealed by three-way species comparisons". United States. doi:10.1101/gr.142200.
@article{osti_771850,
title = {Active conservation of noncoding sequences revealed by three-way species comparisons},
author = {Dubchak, I. and Mayor, C. and Brudno, M. and Pachter, L. and Rubin, E.M. and Frazer, K.A.},
abstractNote = {Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.},
doi = {10.1101/gr.142200},
journal = {Genome Research},
number = 9,
volume = 10,
place = {United States},
year = {2000},
month = {5}
}