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Title: Microdosimetry for Boron Neutron Capture Therapy

Abstract

The specific aims of the research proposal were as follows: (1) To design and construct small volume tissue equivalent proportional counters for the dosimetry and microdosimetry of high intensity thermal and epithermal neutron beams used in BNCT, and of modified fast neutron beams designed for boron neutron capture enhanced fast neutron therapy (BNCEFNT). (2) To develop analytical methods for estimating the biological effectiveness of the absorbed dose in BNCT and BNCEFNT based on the measured microdosimetric spectra. (3) To develop an analytical framework for comparing the biological effectiveness of different epithermal neutron beams used in BNCT and BNCEFNT, based on correlated sets of measured microdosimetric spectra and radiobiological data. Specific aims (1) and (2) were achieved in their entirety and are comprehensively documented in Jay Burmeister's Ph.D. dissertation entitled ''Specification of physical and biologically effective absorbed dose in radiation therapies utilizing the boron neutron capture reaction'' (Wayne State University, 1999). Specific aim (3) proved difficult to accomplish because of a lack of sufficient radiobiological data.

Authors:
;
Publication Date:
Research Org.:
Wayne State Univ., Detroit, MI (US)
Sponsoring Org.:
USDOE Office of Energy Research (ER) (US)
OSTI Identifier:
770637
DOE Contract Number:  
FG02-96ER62217
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: 5 Sep 2000
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; EPITHERMAL NEUTRONS; FAST NEUTRONS; NEUTRON CAPTURE THERAPY; NEUTRON REACTIONS; PROPORTIONAL COUNTERS; RADIATION DOSES; BORON; DESIGN; FABRICATION; MICRODOSIMETRY; BORON NEUTRON CAPTURE THERAPY; RADIOBIOLOGICAL EFFECTIVENESS

Citation Formats

Maughan, R L, and Kota, C. Microdosimetry for Boron Neutron Capture Therapy. United States: N. p., 2000. Web. doi:10.2172/770637.
Maughan, R L, & Kota, C. Microdosimetry for Boron Neutron Capture Therapy. United States. doi:10.2172/770637.
Maughan, R L, and Kota, C. Tue . "Microdosimetry for Boron Neutron Capture Therapy". United States. doi:10.2172/770637. https://www.osti.gov/servlets/purl/770637.
@article{osti_770637,
title = {Microdosimetry for Boron Neutron Capture Therapy},
author = {Maughan, R L and Kota, C},
abstractNote = {The specific aims of the research proposal were as follows: (1) To design and construct small volume tissue equivalent proportional counters for the dosimetry and microdosimetry of high intensity thermal and epithermal neutron beams used in BNCT, and of modified fast neutron beams designed for boron neutron capture enhanced fast neutron therapy (BNCEFNT). (2) To develop analytical methods for estimating the biological effectiveness of the absorbed dose in BNCT and BNCEFNT based on the measured microdosimetric spectra. (3) To develop an analytical framework for comparing the biological effectiveness of different epithermal neutron beams used in BNCT and BNCEFNT, based on correlated sets of measured microdosimetric spectra and radiobiological data. Specific aims (1) and (2) were achieved in their entirety and are comprehensively documented in Jay Burmeister's Ph.D. dissertation entitled ''Specification of physical and biologically effective absorbed dose in radiation therapies utilizing the boron neutron capture reaction'' (Wayne State University, 1999). Specific aim (3) proved difficult to accomplish because of a lack of sufficient radiobiological data.},
doi = {10.2172/770637},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {9}
}