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Title: DNA Repair Enzyme-Liposomes: Human Skin Cancer Prevention

Abstract

This project centered on responses of human cells to ultraviolet radiation at the fundamental and practical levels. At the fundamental levels, the relation of DNA damage to cell signaling events such as cytokine induction were studied; paths in human cells for dealing with DNA damage were studied at the nucleotide sequence level. At the practical, new, effective and inexpensive UVB filters were devised and characterized; further, to make low frequency DNA damage quantitation more generally available, a commercially-obtainable electrophoretic mode (Contour Clamped Homogeneous Electric Field) was tested and determined to give good dispersions of high molecular length DNAs.

Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
770453
Report Number(s):
BNL-83313-1999
CRADA # BNL-C-95-04
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Progress Report; DNA Repair; Enzymes; Liposomes; Skin Diseases; Neoplasms

Citation Formats

None. DNA Repair Enzyme-Liposomes: Human Skin Cancer Prevention. United States: N. p., 1999. Web. doi:10.2172/770453.
None. DNA Repair Enzyme-Liposomes: Human Skin Cancer Prevention. United States. doi:10.2172/770453.
None. Thu . "DNA Repair Enzyme-Liposomes: Human Skin Cancer Prevention". United States. doi:10.2172/770453. https://www.osti.gov/servlets/purl/770453.
@article{osti_770453,
title = {DNA Repair Enzyme-Liposomes: Human Skin Cancer Prevention},
author = {None},
abstractNote = {This project centered on responses of human cells to ultraviolet radiation at the fundamental and practical levels. At the fundamental levels, the relation of DNA damage to cell signaling events such as cytokine induction were studied; paths in human cells for dealing with DNA damage were studied at the nucleotide sequence level. At the practical, new, effective and inexpensive UVB filters were devised and characterized; further, to make low frequency DNA damage quantitation more generally available, a commercially-obtainable electrophoretic mode (Contour Clamped Homogeneous Electric Field) was tested and determined to give good dispersions of high molecular length DNAs.},
doi = {10.2172/770453},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {9}
}