DNA Repair Enzyme-Liposomes: Human Skin Cancer Prevention

doi:10.2172/770453

Title: DNA Repair Enzyme-Liposomes: Human Skin Cancer Prevention

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Abstract

This project centered on responses of human cells to ultraviolet radiation at the fundamental and practical levels. At the fundamental levels, the relation of DNA damage to cell signaling events such as cytokine induction were studied; paths in human cells for dealing with DNA damage were studied at the nucleotide sequence level. At the practical, new, effective and inexpensive UVB filters were devised and characterized; further, to make low frequency DNA damage quantitation more generally available, a commercially-obtainable electrophoretic mode (Contour Clamped Homogeneous Electric Field) was tested and determined to give good dispersions of high molecular length DNAs.

Publication Date:: Thu Sep 16 00:00:00 EDT 1999

Research Org.:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE Office of Science (SC)

OSTI Identifier:: 770453

Report Number(s):: BNL-83313-1999
CRADA # BNL-C-95-04

DOE Contract Number:: AC02-98CH10886

Resource Type:: Technical Report

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; Progress Report; DNA Repair; Enzymes; Liposomes; Skin Diseases; Neoplasms

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                    . DNA Repair Enzyme-Liposomes: Human Skin Cancer Prevention.  United States: N. p., 1999. 
        Web.  doi:10.2172/770453.

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                    . DNA Repair Enzyme-Liposomes: Human Skin Cancer Prevention.  United States.  https://doi.org/10.2172/770453

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                    . 1999.  
        "DNA Repair Enzyme-Liposomes: Human Skin Cancer Prevention".  United States.  https://doi.org/10.2172/770453.  https://www.osti.gov/servlets/purl/770453.

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@article{osti_770453,

  title        = {DNA Repair Enzyme-Liposomes: Human Skin Cancer Prevention},

  author       = {},

  abstractNote = {This project centered on responses of human cells to ultraviolet radiation at the fundamental and practical levels. At the fundamental levels, the relation of DNA damage to cell signaling events such as cytokine induction were studied; paths in human cells for dealing with DNA damage were studied at the nucleotide sequence level. At the practical, new, effective and inexpensive UVB filters were devised and characterized; further, to make low frequency DNA damage quantitation more generally available, a commercially-obtainable electrophoretic mode (Contour Clamped Homogeneous Electric Field) was tested and determined to give good dispersions of high molecular length DNAs.},

  doi          = {10.2172/770453},

  url          = {https://www.osti.gov/biblio/770453},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Thu Sep 16 00:00:00 EDT 1999},

  month        = {Thu Sep 16 00:00:00 EDT 1999}

}

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