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Title: Recent developments in tritium incorporation for radiotracer studies

Abstract

The essential nature of rapid radiotracer synthesis very early in drug discovery programs has driven the need for better and more varied tritium incorporation methods. This review presents a summary of recent advances for tritium introduction via tritiated water, tritium gas, complex tritides, and a range of recently improved tritiation reagents. Access to a wider range of tritiated reagents (for tritioacetylation, tritioformylation, methlylation, etc.) and commercial manifolds for the transfer and use of tritium gas is also discussed.

Authors:
;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
National Institutes of Health (US)
OSTI Identifier:
767597
Report Number(s):
LBNL-45765
R&D Project: 865036; TRN: US0005609
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Journal Article
Journal Name:
Current Pharmaceutical Design
Additional Journal Information:
Journal Volume: 6; Journal Issue: 10; Other Information: PBD: 28 Apr 2000
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; SYNTHESIS; TRITIDES; TRITIUM; TRITIUM OXIDES; TRACER TECHNIQUES; TRITIUM INCORPORATION

Citation Formats

Saljoughian, Manouchehr, and Williams P.G. Recent developments in tritium incorporation for radiotracer studies. United States: N. p., 2000. Web. doi:10.2174/1381612003399969.
Saljoughian, Manouchehr, & Williams P.G. Recent developments in tritium incorporation for radiotracer studies. United States. doi:10.2174/1381612003399969.
Saljoughian, Manouchehr, and Williams P.G. Fri . "Recent developments in tritium incorporation for radiotracer studies". United States. doi:10.2174/1381612003399969.
@article{osti_767597,
title = {Recent developments in tritium incorporation for radiotracer studies},
author = {Saljoughian, Manouchehr and Williams P.G.},
abstractNote = {The essential nature of rapid radiotracer synthesis very early in drug discovery programs has driven the need for better and more varied tritium incorporation methods. This review presents a summary of recent advances for tritium introduction via tritiated water, tritium gas, complex tritides, and a range of recently improved tritiation reagents. Access to a wider range of tritiated reagents (for tritioacetylation, tritioformylation, methlylation, etc.) and commercial manifolds for the transfer and use of tritium gas is also discussed.},
doi = {10.2174/1381612003399969},
journal = {Current Pharmaceutical Design},
number = 10,
volume = 6,
place = {United States},
year = {2000},
month = {4}
}