Recent developments in tritium incorporation for radiotracer studies

Journal Article · Fri Apr 28 00:00:00 EDT 2000 · Current Pharmaceutical Design

DOI:https://doi.org/10.2174/1381612003399969· OSTI ID:767597

Saljoughian, Manouchehr; Williams, P G

The essential nature of rapid radiotracer synthesis very early in drug discovery programs has driven the need for better and more varied tritium incorporation methods. This review presents a summary of recent advances for tritium introduction via tritiated water, tritium gas, complex tritides, and a range of recently improved tritiation reagents. Access to a wider range of tritiated reagents (for tritioacetylation, tritioformylation, methlylation, etc.) and commercial manifolds for the transfer and use of tritium gas is also discussed.

• Research Organization: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
• Sponsoring Organization: National Institutes of Health (US)
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 767597
• Report Number(s): LBNL-45765; R&D Project: 865036; TRN: US0005609
• Journal Information: Current Pharmaceutical Design, Vol. 6, Issue 10; Other Information: PBD: 28 Apr 2000
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
SYNTHESIS
TRITIDES
TRITIUM
TRITIUM OXIDES
TRACER TECHNIQUES
TRITIUM INCORPORATION