Polymorphism of the human factor H-related gene (FHR-1) and of factor H in a West African individual

Journal Article · Wed Mar 01 00:00:00 EST 1995 · Immunogenetics

DOI:https://doi.org/10.1007/BF00172164· OSTI ID:75570

Meyer, C G ^[1]; Skerka, C; Zipfel, P F ^[2]

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1. Institute for Tropical Medicine, Berlin (Germany)
2. Bernhard Nocht Institute for Tropical Medicine, Hamburg (Germany)

The human factor H-related 1 (FHR-1) protein is structurally and immunogenically related to the regulatory complement protein factor H (FH). Polymorphism of the FHR-1 gene is indicated by the nucleotide differences as described by the five cDNA clones isolated so far. In order to further analyze this polymorphism we identified PCR-primers which allow the simultaneous amplification of FHR-1 and FH alleles in a single polymerase chain reaction (PCR). By DNA sequence analysis, two novel FHR-1 variants and one as yet unrecognized FH allele could be characterized in an individual from Benin, West Africa. 2 refs., 1 fig.

• Sponsoring Organization: USDOE
• OSTI ID: 75570
• Journal Information: Immunogenetics, Vol. 41, Issue 5; Other Information: PBD: Mar 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
STRUCTURE-ACTIVITY RELATIONSHIPS
HUMAN CHROMOSOMES
DNA-CLONING
AMINO ACID SEQUENCE
BENIN
PATIENTS
NUCLEOTIDES
PROTEINS
POLYMERASE CHAIN REACTION