Comparison of the cytological effects produced by ionizing radiations of different LET. Three-year summary of project activities from April 1973--April 1976. [X radiation, fission neutrons, mice, rats]
In the past 3 years, we have irradiated about 600 mice with single or fractionated doses of x-rays or fission neutrons and have tested the lens epithelia by wounding at 1 hour, 1 week, 2 weeks, or 4 weeks post-irradiation, irradiated about 900 rats with a single dose from a graded series of single doses of x-rays or fission neutrons and tested the lens epithelia by wounding at 3, 14, or 28 days post-irradiation (plus about 100 control lens epithelia), irradiated either half of a rat lens or the entire lens to compare the immediate effects on the wound response and recovery rates in the half-irradiated and whole-irradiated epithelia, and done a pilot study on cAMP and RNA synthesis in the hours soon after wounding. Most of our results indicate an RBE from 4 to 5. Our data usually show a continual recovery during the first month after x-irradiation. The neutron irradiated tissues often show little recovery during the first week or two, but then ''catch up'' to the recovering x-irradiated tissues. Fractionation usually results in a ''sparing effect'' but fractionation of neutron doses enhanced the effect on a cell population with a slow, but steady cell turnover rate. Shielding half a lens enables the irradiated cells to recover faster.
- Research Organization:
- Iowa Univ., Iowa City (USA). Radiation Research Lab.
- DOE Contract Number:
- E(11-1)-1024
- OSTI ID:
- 7345000
- Report Number(s):
- COO-1024-56
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AMP
BIOSYNTHESIS
CRYSTALLINE LENS
BIOLOGICAL RADIATION EFFECTS
EPITHELIUM
EYES
FISSION NEUTRONS
RBE
FRACTIONATED IRRADIATION
RNA
WOUNDS
MICE
RATS
SHIELDING
X RADIATION
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BODY
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FERMIONS
HADRONS
INJURIES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NEUTRONS
NUCLEIC ACIDS
NUCLEONS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SENSE ORGANS
SYNTHESIS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals