Functional capacity and cryopreservation of fetal rat pancreas in streptozotocin-diabetes. [Effectiveness of transplantation of fetal pancreas for control of diabetes in adult rats]
The fetal rat pancreas has a marked capacity for growth and maturation in glucose responsivity after transplantation under the kidney capsules of adult rats. The optimal conditions for function of the organ are a 3-week period of growth in a normal rat before transfer to a diabetic animal. Under these conditions diabetes is completely reversed by one fetal pancreas, and glucose disappearance rate and plasma insulin response to glucose are normal. Shunting of the venous drainage into the liver from fetal pancreases placed beneath the kidney capsule results in a marked improvement in diabetes control, and this technique may prove useful in experimental or human applications. Cryopreservation of the fetal pancreas has been successfully accomplished and will serve as a useful adjuvant to this method of reversing experimental diabetes.
- Research Organization:
- California Univ., Los Angeles (USA); Oak Ridge National Lab., Tenn. (USA)
- DOE Contract Number:
- W-7405-ENG-26; NIH-G-AM-17980
- OSTI ID:
- 7334072
- Report Number(s):
- CONF-761054-1
- Resource Relation:
- Conference: 9. congress of the International Diabetes Federation, New Delhi, India, 31 Oct 1976
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DIABETES MELLITUS
THERAPY
PANCREAS
TRANSPLANTS
BIOLOGICAL REGENERATION
BLOOD PLASMA
CHEMICAL COMPOSITION
CONTROL
CRYOGENICS
FETUSES
FREEZING
GLUCOSE
GRAFT-HOST REACTION
IN VIVO
INSULIN
PRESERVATION
RATS
TISSUE CULTURES
ALDEHYDES
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BLOOD
BODY
BODY FLUIDS
CARBOHYDRATES
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HEXOSES
HORMONES
MAMMALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
RECOVERY
RODENTS
SACCHARIDES
VERTEBRATES
550000* - Biomedical Sciences
Basic Studies